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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of paroxetine tablets in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated any benefit to using paroxetine in children with depression. Studies have shown that some children, teenagers, and young adults think about suicide or attempt suicide when taking the medicine. Because of this toxicity, use in children is not recommended.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of paroxetine in the elderly. However, elderly patients may be more sensitive to the effects of this medicine than younger adults, which may require caution and an adjustment in the dose for patients receiving paroxetine.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
Breastfeeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Clorgyline
- Furazolidone
- Iproniazid
- Isocarboxazid
- Linezolid
- Metoclopramide
- Moclobemide
- Nialamide
- Pargyline
- Phenelzine
- Pimozide
- Procarbazine
- Selegiline
- Thioridazine
- Toloxatone
- Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abciximab
- Acenocoumarol
- Almotriptan
- Anagrelide
- Ancrod
- Anisindione
- Antithrombin III Human
- Ardeparin
- Aspirin
- Bivalirudin
- Certoparin
- Cilostazol
- Clopidogrel
- Dalteparin
- Danaparoid
- Defibrotide
- Dermatan Sulfate
- Desirudin
- Desvenlafaxine
- Dexfenfluramine
- Dextromethorphan
- Dicumarol
- Dipyridamole
- Droperidol
- Duloxetine
- Eletriptan
- Enoxaparin
- Epoprostenol
- Eptifibatide
- Fenfluramine
- Fondaparinux
- Frovatriptan
- Heparin
- Iloprost
- Lamifiban
- Lexipafant
- Milnacipran
- Nadroparin
- Naratriptan
- Nefazodone
- Parnaparin
- Pentosan Polysulfate Sodium
- Phenindione
- Phenprocoumon
- Rasagiline
- Reviparin
- Rizatriptan
- Sibrafiban
- Sibutramine
- St John's Wort
- Sulfinpyrazone
- Sulodexide
- Sumatriptan
- Tapentadol
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tramadol
- Trazodone
- Tryptophan
- Warfarin
- Xemilofiban
- Zolmitriptan
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Alclofenac
- Amitriptyline
- Amoxapine
- Aprepitant
- Asenapine
- Benoxaprofen
- Bromfenac
- Bufexamac
- Bupropion
- Carprofen
- Celecoxib
- Cimetidine
- Clarithromycin
- Clomipramine
- Clonixin
- Clozapine
- Cyproheptadine
- Darunavir
- Desipramine
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Dothiepin
- Doxepin
- Droxicam
- Encainide
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenbufen
- Fenoprofen
- Fentiazac
- Flecainide
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Fluphenazine
- Flurbiprofen
- Fosamprenavir
- Fosphenytoin
- Galantamine
- Ginkgo
- Ibuprofen
- Iloperidone
- Imipramine
- Indomethacin
- Indoprofen
- Isoxicam
- Ketoprofen
- Ketorolac
- Lithium
- Lofepramine
- Lornoxicam
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Metoprolol
- Morniflumate
- Nabumetone
- Naproxen
- Niflumic Acid
- Nimesulide
- Nortriptyline
- Oxaprozin
- Paliperidone
- Parecoxib
- Perhexiline
- Perphenazine
- Phenylbutazone
- Phenytoin
- Pirazolac
- Piroxicam
- Pirprofen
- Procyclidine
- Propafenone
- Propyphenazone
- Proquazone
- Protriptyline
- Quinidine
- Risperidone
- Ritonavir
- Rofecoxib
- Sulindac
- Suprofen
- Tamoxifen
- Tenidap
- Tenoxicam
- Tetrabenazine
- Tiaprofenic Acid
- Tolmetin
- Trimipramine
- Valdecoxib
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bipolar disorder (mood disorder with alternating episodes of mania and depression), or risk of or
- Bleeding problems or
- Glaucoma, narrow angle
- Hyponatremia (low sodium in the blood) or
- Seizures, history of—Use with caution. May make these conditions worse.
- Diseases affecting metabolism or diseases involving blood circulation—Caution should be used in patients with these medical problems.
- Heart disease, unstable or
- Heart attack, recent history of—The effects of paroxetine in patients with these conditions are not known.
- Kidney disease or
- Liver disease—Use with caution. Higher blood levels of paroxetine may occur, increasing the chance of side effects.
- Mania or hypomania, history of—Use of paroxetine may activate these conditions.
