Paroxetine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Agitation
• Chest congestion
• Chest pain
• Chills
• Cold sweats
• Confusion
• Difficulty with breathing
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
• Fast, pounding, or irregular heartbeat or pulse
• Muscle pain or weakness
• Skin rash

• Absence of or decrease in body movements
• Bigger, dilated, or enlarged pupils (black part of the eye)
• Difficulty with speaking
• Inability to move the eyes
• Incomplete, sudden, or unusual body or facial movements
• Increased sensitivity of the eyes to light
• Low blood sodium (confusion, convulsions [seizures], drowsiness, dryness of the mouth, increased thirst, or lack of energy)
• Red or purple patches on the skin
• Serotonin syndrome (confusion, diarrhea, fever, poor coordination, restlessness, shivering, sweating, talking and acting with excitement you cannot control, trembling or shaking, or twitching)
• Talking, feeling, and acting with excitement and activity you cannot control

• Back, leg, or stomach pains
• Bleeding gums
• Blindness
• Blistering, peeling, or loosening of the skin
• Bloated, full feeling
• Bloody or black, tarry stools
• Bloody urine
• Blue-yellow color blindness
• Blurred vision
• Coma
• Constipation
• Cough or hoarseness
• Dark urine
• Decreased frequency or amount of urine
• Decreased vision
• Depression
• Difficulty opening the mouth
• Difficulty with swallowing
• Electric shock sensations
• Epileptic seizure that will not stop
• Excessive muscle tone
• Eye pain
• Fainting
• Fixed position of the eye
• Fluid-filled skin blisters
• General body swelling
• General feeling of tiredness or weakness
• Headache
• High fever
• Hives
• Inability to move the arms and legs
• Inability to sit still
• Increased blood pressure
• Increased sweating
• Increased thirst
• Incremental or ratchet-like movement of the muscle
• Indigestion
• Itching skin
• Joint pain
• Light-colored stools
• Lockjaw
• Loss of appetite
• Loss of bladder control
• Low blood pressure
• Lower back or side pain
• Muscle spasm, especially of the neck and back
• Muscle tension or tightness
• Nausea
• Need to keep moving
• Nosebleeds
• Painful knees and ankles
• Painful or difficult urination
• Painful or prolonged erection of the penis
• Pale skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Raised red swellings on the skin, the buttocks, legs, or ankles
• Red, irritated eyes
• Rigid muscles
• Seizure or coma late in pregnancy
• Sensitivity to the sun
• Shortness of breath
• Skin redness or soreness
• Skin sores, welts, or blisters
• Skin thinness
• Slow heart rate
• Slow movement
• Slow reflexes
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Spasms of the throat
• Stiff muscles
• Stomach pain
• Sudden numbness and weakness in the arms and legs
• Swelling of the breasts
• Swelling of the face, fingers, or lower legs
• Swollen or painful glands
• Tightness in the chest
• Unexpected or excess milk flow from the breasts
• Unusual bleeding or bruising
• Unusual or decreased blood cell production
• Unusual tiredness or weakness
• Vomiting
• Weight gain
• Wheezing
• Yellowing of the eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Dizziness
• Drowsiness
• Flushing of the face
• Irritability
• Large pupils
• Racing heartbeat
• Trembling or shaking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Decreased appetite
• Decreased sexual ability or desire
• Excess air or gas in the stomach or intestines
• Heartburn
• Nervousness
• Pain or tenderness around the eyes and cheekbones
• Passing gas
• Problems in urinating
• Runny or stuffy nose
• Sexual problems, especially ejaculatory disturbances
• Sleepiness or unusual drowsiness
• Stomach discomfort, upset, or pain
• Sweating
• Trauma
• Trouble with sleeping

• Abnormal dreams
• Anxiety
• Bladder pain
• Body aches or pain
• Change in sense of taste
• Changes in vision
• Cloudy urine
• Confusion
• Congestion
• Difficulty in focusing the eyes
• Difficulty with moving
• Discouragement, feeling sad, or empty
• Drugged feeling
• Dryness of the throat
• Excessive muscle tone
• Fainting or loss of consciousness
• Fast or irregular breathing
• Feeling of unreality
• Feeling of warmth or heat
• Flushing or redness of the skin, especially on the face and neck
• Frequent urge to urinate
• Headache, severe and throbbing
• Heavy bleeding
• Increase in body movements
• Increased appetite
• Irritability
• Itching of the vagina or genital area
• Itching, pain, redness, or swelling of the eye or eyelid
• Lack of emotion
• Loss of interest or pleasure
• Loss of memory
• Lump in the throat
• Menstrual changes
• Menstrual pain or cramps
• Muscle twitching or jerking
• Pain during sexual intercourse
• Problems with memory
• Problems with tooth
• Rhythmic movement of the muscles
• Sense of detachment from self or body
• Severe sunburn
• Slow heartbeat
• Sneezing
• Thick, white vaginal discharge with no odor or with a mild odor
• Tightness in the throat
• Tingling, burning, or prickling sensations
• Trouble concentrating
• Voice changes
• Watering of the eyes
• Weight loss
• Yawn

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Actions that are out of control
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Crying
• Depersonalization
• Diarrhea
• Dizziness or lightheadedness
• Dysphoria
• Electric shock sensations
• Euphoria
• Fear
• Feeling unwell or unhappy
• Increased sweating
• Irritability
• Muscle pain
• Nervousness
• Paranoia
• Quick to react or overreact emotionally
• Rapidly changing moods
• Talking, feeling, and acting with excitement
• Unusual drowsiness, dullness, or feeling of sluggishness
• Unusual tiredness or weakness
• Vision changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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