Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get StartedPrecautions
Your doctor should check your progress at regular visits. Blood tests may be needed to make sure that this medicine is working properly and is not causing unwanted effects.
Drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of allopurinol. Therefore, people with gout and other people with too much uric acid in the body should be careful to limit the amount of alcohol they drink.
Taking too much vitamin C may make the urine more acidic and increase the possibility of kidney stones forming while you are taking allopurinol. Therefore, check with your doctor before you take vitamin C while taking this medicine.
Check with your doctor immediately:
- If you notice a skin rash, hives, or itching while you are taking allopurinol.
- If chills, fever, joint pain, muscle aches or pains, sore throat, or nausea or vomiting occur, especially if they occur together with or shortly after a skin rash.
Very rarely, these effects may be the first signs of a serious reaction to the medicine.
Allopurinol may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.