Allopurinol (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Agitation
• Coma
• Confusion
• Decreased urine output
• Depression
• Dizziness
• Headache
• Hostility
• Irritability
• Lethargy
• Muscle twitching
• Nausea
• Rapid weight gain
• Seizures
• Stupor
• Swelling of the face, ankles, or hands
• Unusual tiredness or weakness

• Abdominal or stomach pain
• Black, tarry stools
• Bladder pain
• Bleeding gums
• Blood in the urine or stools
• Blurred vision
• Changes in skin color
• Chest pain
• Chills
• Clay-colored stools
• Cloudy urine
• Cough or hoarseness
• Coughing up blood
• Dark urine
• Difficult, burning, or painful urination
• Difficulty with breathing or swallowing
• Difficulty with speaking
• Dilated neck veins
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Double vision
• Enlarged abdomen or stomach
• Extreme fatigue
• Fainting
• Fast or slow heartbeat
• Feeling of warmth
• Fever
• Frequent urge to urinate
• Inability to move the arms, legs, or facial muscles
• Inability to speak
• Increased menstrual flow or vaginal bleeding
• Increased sweating
• Irregular breathing
• Irregular heartbeat
• Itching
• Joint pain, stiffness, or swelling
• Lightheadedness
• Loosening of the fingernails
• Loss of appetite
• Loss of strength or energy
• Lower back or side pain
• Muscle pain or weakness
• Nosebleeds
• Numbness, tingling, pain, or weakness in the hands or feet
• Pain
• Pain, tenderness, or swelling of the foot or leg
• Paralysis
• Pinpoint red spots on the skin
• Prolonged bleeding from cuts
• Rapid, shallow breathing
• Rash
• Red or black, tarry stools
• Red or dark brown urine
• Redness of the face, neck, arms, and occasionally, upper chest
• Shortness of breath
• Slow speech
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sudden shortness of breath or troubled breathing
• Sweating
• Swelling of the fingers, feet, or lower legs
• Swollen glands
• Tightness in the chest
• Troubled breathing
• Unpleasant breath odor
• Unusual bleeding or bruising
• Unusual weak feeling
• Vomiting of blood
• Weight gain
• Wheezing
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Drowsiness
• Indigestion
• Stomach pain
• Unusual hair loss

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Body aches or pain
• Congestion
• Cracked lips
• Difficulty with moving
• Hair loss or thinning of the hair
• Hives or welts
• Itching, pain, redness, swelling, tenderness, or warmth on the skin
• Muscle stiffness
• Redness of the skin
• Runny nose
• Voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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