Bosentan (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Blurred vision
• Confusion
• Dizziness
• Dark urine
• Faintness or lightheadedness when getting up from a lying or sitting position
• Fever with or without chills
• Light-colored stools
• Loss of appetite
• Nausea and vomiting
• Stomach pain
• Sudden sweating
• Unusual tiredness or weakness
• Yellow eyes or skin

• Swelling

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Blue lips and fingernails
• Chest pain
• Chills
• Clay-colored stools
• Coughing that sometimes produces a pink frothy sputum
• Coughing up blood
• Dark urine
• Decrease in the amount of urine
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Fainting
• Fast heartbeat
• Fatigue on exertion
• Fever
• Headache
• Hives
• Hoarseness
• Increased sweating
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Noisy, rattling breathing
• Pale skin
• Pinpoint red spots on the skin
• Rash
• Redness of the skin
• Shortness of breath
• Swelling of the eyelids, face, lips, hands, fingers, legs, ankles, or feet
• Tightness in the chest
• Troubled breathing at rest
• Troubled breathing or swallowing
• Troubled breathing with exertion
• Unpleasant breath odor
• Unusual bleeding or bruising
• Vomiting of blood
• Weight gain
• Wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

• Increased heart rate

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Fast, irregular, pounding, or racing heartbeat or pulse
• Feeling of warmth
• Muscle aches
• Redness of the face, neck, arms, and occasionally upper chest
• Sore throat
• Stuffy or runny nose

• Acid or sour stomach
• Belching
• Heartburn
• Indigestion
• Stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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