Onabotulinumtoxina (Injection Route, Intradermal Route, Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Difficulty with swallowing

• Difficulty with breathing or speaking
• Muscle weakness

• Dryness of the eyes
• Inability to close the eyelids completely

• Bladder pain
• Bloody or cloudy urine
• Difficult, burning, or painful urination
• Frequent urge to urinate
• Lower back or side pain

• Decreased blinking
• Irritation of the cornea (colored portion) of the eyes
• Turning outward or inward of the edge of the eyelids

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Blue or purplish bruise on the eyelids
• Drooping of the upper eyelids
• Irritation or watering of the eyes
• Sensitivity of the eyes to light

• Body aches or pain
• Chills
• Cough, fever, sneezing, or sore throat
• Ear congestion
• Headache
• Loss of voice
• Nasal congestion
• Neck pain
• Runny nose
• Unusual tiredness or weakness

• Neck pain

• Body aches or pain
• Chills
• Congestion
• Cough
• Diarrhea
• Dryness or soreness of the throat
• Fear
• Fever
• General feeling of discomfort or illness
• Headache
• Heavy bleeding from the place where shot was given
• Itching skin
• Joint pain
• Loss of appetite
• Nausea
• Nervousness
• Painful or difficult urination
• Runny nose
• Shivering
• Sweating
• Tender, swollen glands in the neck
• Trouble sleeping
• Trouble swallowing
• Voice changes
• Vomiting

• Drooping of the upper eyelid
• Eye pointing upward or downward instead of straight ahead

• Muscle weakness
• Pain in the arms

• Skin rash
• Swelling of the eyelid skin

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Blurred vision
• Body aches or pain
• Cough producing mucus
• Difficulty breathing
• Dizziness
• Drooping of the upper eyelid
• Headache
• Muscle aches and pains
• Nervousness
• Pounding in the ears
• Shortness of breath
• Slow or fast heartbeat
• Tightness in the chest
• Wheezing

• Difficulty finding the location of objects
• Double vision

• Cough producing mucus
• Difficulty breathing
• Nausea
• Shortness of breath
• Tightness in the chest
• Weakness
• Wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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