Hydroxyurea (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Cough or hoarseness
• Fever or chills
• Lower back or side pain
• Painful or difficult urination

• Black, tarry stools
• Blackening of the fingernails and toenails
• Blood in the urine or stools
• Pinpoint red spots on the skin
• Sores in the mouth and on the lips
• Unusual bleeding or bruising

• Confusion
• Convulsions (seizures)
• Difficulty with urination
• Dizziness
• Headache
• Joint pain
• Seeing, hearing, or feeling things that are not there
• Swelling of the feet or lower legs

• Bleeding under the skin
• Blisters on the skin
• Bluish or pale color on the skin of the fingers or toes
• Coldness of the fingers or toes
• Crater-like lesions on the skin
• Itching skin
• Numbness or tingling of the fingers or toes
• Pain in the fingers or toes
• Unusual tiredness or weakness
• Weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

• Scaling of the skin on the hands and feet
• Severe darkening of skin color
• Soreness
• Sores in the mouth and on the lips
• Swelling of the palms and soles of the feet
• Violet flushing of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Drowsiness
• Loss of appetite
• Nausea or vomiting

• Constipation
• Redness of skin at the place of irradiation
• Skin rash and itching

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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