Mesalamine (Rectal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Abdominal or stomach cramps or pain (severe)
• Anxiety
• Back pain (severe)
• Bloody, black, or tarry stools
• Blue or pale skin
• Bright red blood in the stool
• Chest pain, possibly moving to the left arm, neck, or shoulder
• Chills
• Diarrhea (severe)
• Fast heartbeat
• Fever
• Headache (severe)
• Nausea or vomiting
• Shortness of breath
• Skin rash
• Stomach cramps, tenderness, pain
• Swelling of the stomach
• Unusual tiredness or weakness
• Watery or bloody diarrhea
• Yellow eyes or skin

• Blood in urine
• Change in frequency of urination or amount of urine
• Cough
• Difficulty in breathing
• Drowsiness
• High fever
• Increased thirst
• Loss of appetite
• Lower back or side pain
• Painful or difficult urination
• Pale skin
• Sore throat
• Sores, ulcers, or white spots on lips or in mouth
• Swelling of feet or lower legs
• Swollen glands
• Troubled breathing
• Unexplained or unusual bleeding or bruising
• Weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach cramps or pain (mild)
• Gas or flatulence
• Headache (mild)
• Nausea

• Acne
• Diarrhea
• Dizziness
• Leg or joint pain
• Loss of hair
• Rectal pain or irritation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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