Methylphenidate (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Fast heartbeat

• Chest pain
• Fever
• Joint pain
• Skin rash or hives

• Black, tarry stools
• Blood in the urine or stools
• Blurred vision or other changes in vision
• Convulsions
• Crusting, dryness, or flaking of the skin
• Muscle cramps
• Pinpoint red spots on the skin
• Scaling, severe redness, soreness, or swelling of the skin
• Uncontrolled vocal outbursts or tics (uncontrolled and repeated body movements)
• Unusual bleeding or bruising

• Confusion
• Delusions (false beliefs)
• Depersonalization (feeling like surroundings are not real)
• Depression (severe)
• Hallucinations (seeing, hearing, or feeling things that are not there)
• Hives or welts
• Numbness of the hands
• Painful or difficult urination
• Pale skin
• Red, irritated eyes
• Red, swollen, or scaly skin
• Severe or sudden headache
• Shortness of breath
• Sores, ulcers, or white spots on the lips or in the mouth
• Sudden loss of coordination or slurring of speech
• Unusual behavior
• Unusual tiredness or weakness
• Weight loss
• Yellow skin or eyes

Get emergency help immediately if any of the following symptoms of overdose occur:

• Agitation
• Confusion (severe)
• Convulsions
• Dryness of the mouth or mucous membranes
• False sense of well-being
• Fast, pounding, or irregular heartbeat
• Flushing
• Hallucinations (seeing, hearing, or feeling things that are not there)
• Headache (severe)
• Increased sweating
• Large pupils
• Muscle twitching
• Sweating
• Trembling or shaking
• Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Loss of appetite
• Nervousness
• Sleeplessness
• Stuffy nose
• Trouble with sleeping
• Unable to sleep
• Unusually warm skin

• Anger
• Dizziness
• Drowsiness
• Fear
• Headache
• Irritability
• Muscle aches
• Nausea
• Nervousness
• Runny nose
• Scalp hair loss
• Stomach pain
• Talking, feeling, and acting with excitement

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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