Lenalidomide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Chest pain
• Chills
• Convulsions
• Cough
• Decreased urine
• Difficult or labored breathing
• Dry mouth
• Fever
• Increased thirst
• Irregular heartbeat
• Loss of appetite
• Lower back or side pain
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Numbness or tingling in the hands, feet, or lips
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen glands
• Tightness in the chest
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Wheezing

• Anxiety
• Dizziness or lightheadedness
• Fainting
• Fast heartbeat
• Pain, redness, or swelling in the arm or leg
• Sudden shortness of breath or troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abnormal or decreased touch sensation
• Back pain
• Bloody nose
• Blurred vision
• Body aches or pain
• Bruising
• Burning while urinating
• Burning, numbness, tingling, or painful sensations
• Change in taste
• Contusion
• Cough-producing mucus
• Depressed mood
• Diarrhea
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Discouragement
• Drowsiness
• Dry skin and hair
• Dryness or soreness of the throat
• Ear congestion
• Fast, slow, irregular, pounding, or racing heartbeat or pulse
• Feeling sad or empty
• Feeling unusually cold
• Flushing, redness of the skin
• Hair loss
• Headache
• Hoarseness or husky voice
• Irritability
• Itching skin
• Itching, pain, redness, swelling, tenderness, or warmth on the skin
• Lack or loss of strength
• Large, flat, blue or purplish patches in the skin
• Loose stools
• Loss of appetite
• Loss of interest or pleasure
• Loss of taste
• Loss of voice
• Muscle aching
• Muscle spasms, stiffness, or twitching
• Nervousness
• Night sweats
• Pain
• Pain in the arms or legs
• Pain in the joints
• Pain or tenderness around the eyes and cheekbones
• Pounding in the ears
• Rash
• Seizures
• Shivering
• Sleeplessness
• Sneezing
• Stomach pain
• Stuffy or runny nose
• Sweating increased
• Swelling of the hands, ankles, feet, or lower legs
• Swollen joints
• Tender, swollen glands in the neck
• Tiredness
• Trembling
• Trouble with concentrating
• Trouble with sleeping
• Trouble with swallowing
• Troubled breathing with exertion
• Unable to sleep
• Unsteadiness or awkwardness
• Unusually warm skin
• Upper abdomen or stomach pain
• Voice changes
• Vomiting
• Weakness in the arms, hands, legs, or feet
• Weight gain
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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