Bevacizumab (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Body aches or pain
• Burning, tingling, numbness, or pain in the hands, arms, feet, or legs
• Chest pain or discomfort
• Chills
• Cloudy urine
• Convulsions
• Cough
• Cracks in the skin
• Decreased urine output
• Difficult or labored breathing
• Dilated neck veins
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Ear congestion
• Extreme fatigue
• Fever
• High blood pressure
• Irregular breathing
• Irregular heartbeat
• Lack or loss of strength
• Lightheadedness
• Loss of appetite
• Loss of heat from the body
• Loss of voice
• Mood changes
• Nasal congestion
• Nervousness
• Pain
• Pain, redness, or swelling in the arm or leg
• Painful or difficult urination
• Pinpoint red spots on the skin
• Pounding in the ears
• Rapid breathing
• Redness
• Runny nose
• Sensation of pins and needles
• Shortness of breath
• Slow or fast heartbeat
• Sore throat
• Sores on the skin
• Sores, ulcers, or white spots on the lips or in the mouth
• Stabbing pain
• Sunken eyes
• Sweating
• Swelling of the face, fingers, feet, or lower legs
• Swelling or inflammation of the mouth
• Swollen glands
• Thirst
• Tightness in the chest
• Trouble with breathing
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of blood or material that looks like coffee grounds
• Watery or bloody diarrhea
• Weight gain
• Wheezing
• Wrinkled skin
• Yellow skin

• Abdominal or stomach pain
• Bone pain
• Difficulty having a bowel movement (stool)
• Difficulty with swallowing
• Fainting
• Severe constipation
• Severe vomiting
• Stomach tenderness

• Back pain
• Blisters
• Blurred vision
• Coma
• Confusion
• Dizziness
• Drowsiness
• Headache
• Increased thirst
• Muscle pain or cramps
• Open sores
• Pale skin

• Bloody mucus or unexplained nosebleeds
• Hoarseness
• Sudden weakness in the arms or legs
• Sudden, severe chest pain
• Voice changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Bloody nose
• Change in taste or bad unusual or unpleasant (after) taste
• Change in walking and balance
• Clumsiness or unsteadiness
• Diarrhea
• Dry mouth
• Excess flow of tears
• Hair loss
• Heartburn
• Indigestion
• Low blood pressure
• Stomach discomfort, upset, or pain
• Thinning of the hair
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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