Estradiol and Medroxyprogesterone (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Bloating or swelling of face, hands, lower legs and/or feet
  • Cough
  • Difficulty swallowing
  • Dizziness
  • Fast heartbeat
  • Hives
  • Itching
  • Loss of appetite and nausea
  • Puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • Rapid weight gain
  • Shortness of breath
  • Tightness in chest
  • Unusual tiredness or weakness
  • Vomiting blood
  • Wheezing
  • Yellow eyes or skin
Symptoms of overdose—More common
  • Nausea
  • Menstrual irregularities
  • Vaginal bleeding
  • Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal pain or enlarged abdomen
  • Absent or missed menstrual periods
  • Acne
  • Allergic rash
  • Brown, blotchy spots on skin
  • Decreased sex drive
  • Depression
  • Hair loss/thinning of hair
  • Headache
  • Increased amount of menstrual bleeding, or normal bleeding that comes earlier
  • Lack or loss of strength
  • Nervousness
  • Quick to react or overact emotionally
  • Rapidly changing moods
  • Stopping of menstrual bleeding over several months
  • Vaginal yeast infection
  • Weight change
Precautions
DR601891 Portions of this document last updated: Dec. 1, 2012

Source: Drug Information provided by: Micromedex

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