Didanosine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Nausea and vomiting
• Stomach pain
• Tingling, burning, numbness, and pain in the hands or feet

• Convulsions (seizures)
• Fever and chills
• Shortness of breath
• Skin rash and itching
• Sore throat
• Swelling of the feet or lower legs
• Unusual bleeding and bruising
• Unusual tiredness and weakness
• Yellow skin and eyes

• Abdominal or stomach discomfort
• Anxiety
• Black, tarry stools
• Bleeding gums
• Blindness
• Bloating
• Blood in the urine or stools
• Blue-yellow color blindness
• Blurred vision
• Change in the color of the eye
• Chest pain
• Clay colored stools
• Cold sweats
• Coma
• Confusion
• Constipation
• Cool, pale skin
• Cough
• Dark urine
• Decreased appetite
• Decreased vision
• Depression
• Diarrhea
• Difficulty with moving
• Difficulty with swallowing
• Dizziness
• Dry eyes
• Dry mouth
• Eye pain
• Fast heartbeat
• Fast, shallow breathing
• Flushed, dry skin
• Fruit-like breath odor
• General feeling of discomfort
• Headache
• Hives
• Increased hunger
• Increased thirst
• Increased urination
• Indigestion
• Joint pain
• Light-colored stools
• Loss of appetite
• Loss of consciousness
• Muscle aching, cramping, or pain
• Nervousness
• Nightmares
• Painful or difficult urination
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Right upper abdominal pain and fullness
• Shakiness
• Sleepiness
• Slurred speech
• Sores, ulcers, or white spots on the lips or in the mouth
• Stomachache
• Sweating
• Swollen glands
• Swollen joints
• Tightness in the chest
• Troubled breathing with exertion
• Unexplained weight loss
• Unsteadiness or awkwardness
• Weakness in the arms, hands, legs, or feet
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty with sleeping
• Irritability
• Restlessness

• Acid or sour stomach
• Belching
• Excess air or gas in the stomach or intestines
• Full feeling
• Hair loss or thinning of the hair
• Heartburn
• Indigestion
• Lack or loss of strength
• Passing gas
• Redistribution or accumulation of body fat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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