Nicotine (Oral Route, Transdermal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Injury or irritation to mouth, teeth, or dental work—with chewing gum only

• High blood pressure

• Fast or irregular heartbeat
• Hives, itching, rash, redness, or swelling of skin

• Nausea and/or vomiting
• Increased watering of mouth (severe)
• Abdominal or stomach pain (severe)
• Diarrhea (severe)
• Pale skin
• Cold sweat
• Headache (severe)
• Dizziness (severe)
• Disturbed hearing and vision
• Tremor
• Confusion
• Weakness (severe)
• Extreme exhaustion
• Fainting
• Low blood pressure
• Difficulty in breathing (severe)
• Fast, weak, or irregular heartbeat
• Convulsions (seizures)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Belching—with chewing gum and lozenges
• Headache (mild)
• Increased appetite
• Increased watering of mouth (mild)—with chewing gum only
• Jaw muscle ache—with chewing gum only
• Redness, itching, and/or burning at site of application of patch—usually stops within 24 hours
• Sore mouth or throat—with chewing gum only

• Abdominal or stomach pain (mild)
• Change in sense of taste
• Constipation
• Coughing (increased)
• Diarrhea
• Dizziness or lightheadedness (mild)
• Drowsiness
• Dryness of mouth
• Hiccups—with chewing gum and lozenges
• Hoarseness—with chewing gum only
• Indigestion (mild)
• Loss of appetite
• Menstrual pain
• Muscle or joint pain
• Nausea or vomiting (mild)
• Passing of gas
• Sweating (increased)
• Trouble in sleeping or unusual dreams
• Unusual irritability or nervousness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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