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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of pioglitazone and glimepiride combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pioglitazone and glimepiride combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving pioglitazone and glimepiride combination.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alatrofloxacin
- Balofloxacin
- Ciprofloxacin
- Clinafloxacin
- Disopyramide
- Enoxacin
- Fleroxacin
- Flumequine
- Gatifloxacin
- Gemifloxacin
- Grepafloxacin
- Levofloxacin
- Lomefloxacin
- Moxifloxacin
- Norfloxacin
- Ofloxacin
- Pefloxacin
- Prulifloxacin
- Rufloxacin
- Sparfloxacin
- Temafloxacin
- Tolvaptan
- Tosufloxacin
- Trovafloxacin Mesylate
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Aceclofenac
- Acemetacin
- Alclofenac
- Alprenolol
- Apazone
- Atenolol
- Atorvastatin
- Benoxaprofen
- Betaxolol
- Bevantolol
- Bisoprolol
- Bitter Melon
- Bromfenac
- Bucindolol
- Bufexamac
- Carprofen
- Carteolol
- Carvedilol
- Celiprolol
- Clometacin
- Clonixin
- Clorgyline
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dilevalol
- Dipyrone
- Droxicam
- Esmolol
- Ethinyl Estradiol
- Etodolac
- Etofenamate
- Felbinac
- Fenbufen
- Fenofibrate
- Fenoprofen
- Fentiazac
- Fenugreek
- Floctafenine
- Fluconazole
- Flufenamic Acid
- Flurbiprofen
- Gemfibrozil
- Glucomannan
- Guar Gum
- Ibuprofen
- Indomethacin
- Indoprofen
- Iproniazid
- Isocarboxazid
- Isoxicam
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Levobunolol
- Levonorgestrel
- Lornoxicam
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Mepindolol
- Mestranol
- Metipranolol
- Metoprolol
- Moclobemide
- Nabumetone
- Nadolol
- Naproxen
- Nebivolol
- Nialamide
- Niflumic Acid
- Nimesulide
- Norethindrone
- Norgestrel
- Oxaprozin
- Oxprenolol
- Oxyphenbutazone
- Pargyline
- Penbutolol
- Phenelzine
- Phenylbutazone
- Pindolol
- Pirazolac
- Piroxicam
- Pirprofen
- Procarbazine
- Propranolol
- Propyphenazone
- Proquazone
- Psyllium
- Rifampin
- Selegiline
- Sotalol
- St John's Wort
- Sulindac
- Suprofen
- Talinolol
- Tenidap
- Tenoxicam
- Tertatolol
- Tiaprofenic Acid
- Timolol
- Tolmetin
- Toloxatone
- Topiramate
- Tranylcypromine
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol intoxication or
- Debilitation or weakened physical condition or
- Malnutrition or
- Underactive adrenal glands or
- Underactive pituitary gland or
- Any other condition that causes low blood sugar—Patients with these conditions may be more likely to develop low blood sugar while taking this medicine.
- Diabetic ketoacidosis (ketones in the blood) or
- Type 1 diabetes—Should not be used in patients with these conditions. Insulin is needed to control these conditions.
- Fever or
- Infection or
- Surgery or
- Trauma—These conditions may cause temporary problems with blood sugar control and your doctor may want to treat you temporarily with insulin.
- Heart failure, severe or
- Liver disease, active—This medicine should not be used in patients with these conditions.
- Heart or blood vessel disorders or
- Problems with fluid retention and swelling—Use with caution. This medicine may make these conditions worse.
- Kidney problems—Use with caution. Dosage adjustment may be needed.
