Pioglitazone and Glimepiride (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Anxiety
• Bladder pain
• Bloody or cloudy urine
• Blurred vision
• Chills
• Cold sweats
• Coma
• Confusion
• Cool, pale skin
• Depression
• Difficult, burning, or painful urination
• Fast heartbeat
• Frequent urge to urinate
• Headache
• Increased hunger
• Increased weight
• Lower back or side pain
• Nausea
• Nervousness
• Nightmares
• Seizures
• Shakiness
• Slurred speech
• Swelling of the feet or lower legs
• Unusual tiredness or weakness

• Accidental injury
• Loss of appetite
• Pain or swelling in the arms or legs without any injury
• Pale skin
• Stomach pain
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Vomiting
• Weight loss
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Body aches or pain
• Cough
• Diarrhea
• Difficulty with moving
• Dryness or soreness of the throat
• Ear congestion
• Fever
• Hoarseness
• Joint pain
• Loss of voice
• Muscle aching or cramping
• Muscle pains or stiffness
• Runny nose
• Sneezing
• Stuffy nose
• Swollen joints
• Tender, swollen glands in the neck
• Tooth disorder
• Trouble with swallowing
• Voice changes

• Dizziness
• Itching skin
• Lack or loss of strength
• Skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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