Etonogestrel (Intradermal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Breast pain
• Chills
• Cough
• Diarrhea
• Fever
• General feeling of discomfort or illness
• Headache
• Joint pain
• Loss of appetite
• Muscle aches and pain
• Nausea
• Runny nose
• Shivering
• Sore throat
• Sweating
• Trouble sleeping
• Unusual tiredness or weakness
• Vomiting

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Bloating
• Blurred vision or other changes in vision
• Breast discharge
• Breast enlargement
• Burning while urinating
• Difficult or painful urination
• Difficulty with breathing
• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Headache, severe and throbbing
• Hives
• Itching
• Lumps in the breasts
• Nervousness
• Noisy breathing
• Painful or tender cysts in the breasts
• Pounding in the ears
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Slow or fast heartbeat
• Stomach or pelvic discomfort, aching, or heaviness
• Swelling of the hands, ankles, feet, or lower legs
• Tightness in the chest
• Wheezing

• Collection of blood under the skin at the injection site
• Deep, dark purple bruise at the injection site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Blemishes on the skin, pimples
• Body aches or pain
• Crying
• Depersonalization
• Discouragement
• Dysphoria
• Ear congestion
• Euphoria
• Feeling sad or empty
• Hoarseness
• Increased clear or white vaginal discharge
• Increased weight
• Irregular bleeding cycle
• Irritability
• Itching of the vagina or genital area
• Light vaginal bleeding between regular menstrual periods
• Loss of interest or pleasure
• Loss of voice
• Mental depression
• Nasal congestion
• Pain, cramps, or heavy menstrual bleeding
• Pain during sexual intercourse
• Pain or tenderness around the eyes and cheekbones
• Paranoia
• Quick to react or overreact emotionally
• Rapidly changing moods
• Stomach pain
• Tender, swollen glands in the neck
• Thick, white vaginal discharge with no odor or with a mild odor
• Trouble concentrating
• Voice changes

• Abdominal or stomach bloating and cramping
• Abnormal ejaculation
• Abnormal or decreased touch sensation
• Acid or sour stomach
• Belching
• Bone pain
• Burning feeling in the chest or stomach
• Decreased interest in sexual intercourse
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Dull ache or feeling of pressure or heaviness in the legs
• Earache, redness, or swelling in the ear
• Excess air or gas in the stomach or intestines
• Feeling of vaginal pressure
• Feeling of warmth
• Hair loss or thinning of the hair
• Heartburn
• Inability to have or keep an erection
• Increased appetite
• Increased hair growth on the forehead, back, arms, and legs
• Indigestion
• Itching skin near damaged veins
• Lack or loss of strength
• Loss in sexual ability, desire, drive, or performance
• Muscle cramping or stiffness
• Passing gas
• Pelvic pain
• Redness of the face, neck, arms, and occasionally upper chest
• Sleepiness or unusual drowsiness
• Sleeplessness
• Sneezing
• Stomach upset or pain
• Stuffy nose
• Swollen joints
• Tenderness in the stomach area
• Unable to sleep
• Vaginal burning or pain
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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