Rosiglitazone and Glimepiride (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Body aches or pain
• Chills
• Cough
• Difficulty with breathing
• Ear congestion
• Fever
• Headache
• Injury
• Loss of voice
• Nasal congestion
• Runny nose
• Sneezing
• Sore throat
• Unusual tiredness or weakness

• Anxiety
• Blurred vision
• Chest pain or discomfort
• Cold sweats
• Coma
• Confusion
• Cool, pale skin
• Decreased urine output
• Depression
• Dilated neck veins
• Dizziness
• Extreme fatigue
• Fast heartbeat
• Increased hunger
• Irregular breathing
• Irregular heartbeat
• Nausea
• Nervousness
• Nightmares
• Seizures
• Shakiness
• Shortness of breath
• Slurred speech
• Swelling of the face, fingers, feet, or lower legs
• Tightness in the chest
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Weight gain
• Wheezing

• Abdominal or stomach pain or tenderness
• Agitation
• Back, leg, or stomach pains
• Bleeding gums
• Bloody, black, or tarry stools
• Blue lips and fingernails
• Coughing that sometimes produces a pink frothy sputum
• Dark urine
• Decreased appetite
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Fluid-filled skin blisters
• General body swelling
• Hostility
• Increased sweating
• Increased thirst
• Irritability
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Lethargy
• Light-colored stools
• Loss of appetite
• Muscle pain or cramps
• Muscle twitching
• Nosebleeds
• Pain or discomfort in the arms, jaw, back, or neck
• Redness of the skin
• Seizures
• Sensitivity to the sun
• Skin rash
• Skin thinness
• Sores, ulcers, or white spots on the lips or in the mouth
• Stupor
• Sweating
• Swollen glands
• Vomiting
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Lack or loss of strength

• Burning, stinging, itching, or redness of the skin not present before therapy

• Diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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