If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by this medicine. This will also allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Lubiprostone may cause difficulty with breathing, nausea, or severe diarrhea. If your symptoms and condition do not improve within a few days, or if they become worse, check with your doctor.
If you are a woman who can get pregnant, your doctor may want you to have a negative pregnancy test before you will be allowed to take this medicine. Also, use an effective form of birth control to keep from getting pregnant. If you miss a period while you are using this medicine, tell your doctor right away.