Human Papillomavirus Vaccine, Quadrivalent (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Fever

• Black, tarry stools
• Bleeding gums
• Blood in urine or stools
• Blurred vision
• Body aches or pain
• Chills
• Constipation
• Cough
• Depressed mood
• Difficulty with breathing
• Dry mouth
• Dry skin and hair
• Ear congestion
• Feeling cold
• Flushed, dry skin
• Fruit-like breath odor
• Headache
• Hoarseness or husky voice
• Increased hunger
• Increased thirst
• Increased urination
• Loss of consciousness
• Loss of voice
• Muscle cramps and stiffness
• Nasal congestion
• Nausea
• Pinpoint red spots on skin
• Runny nose
• Slowed heartbeat
• Sneezing
• Sore throat
• Stomachache
• Sweating
• Troubled breathing
• Unexplained weight loss
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting

• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Hives
• Itching
• Noisy breathing
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Tightness in the chest
• Wheezing

• Anxiety
• Back pain, sudden and severe
• Back, leg, or stomach pains
• Bloating
• Chest pain
• Convulsions (seizures)
• Dark urine
• Fainting
• General body swelling
• Hives or welts
• Hoarseness
• Inability to move the arms and legs
• Indigestion
• Irritation
• Joint pain, stiffness, or swelling
• Loss of appetite
• Loss of bladder control
• Muscle spasm or jerking of all extremities
• Muscle weakness, sudden and progressing
• Nosebleeds
• Pain in the stomach, side, or abdomen, possibly radiating to the back
• Pain, redness, or swelling in the arm or leg
• Pale skin
• Paralysis
• Rash
• Redness of the skin
• Shakiness and unsteady walk, unsteadiness, trembling, or other problems with muscle control or coordination
• Sudden loss of consciousness
• Sudden numbness and weakness in the arms and legs
• Sudden shortness of breath or troubled breathing
• Swelling of the eyelids, face, lips, hands, or feet
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Red streaks on the skin, swelling, tenderness, pain, or itching at the injection site

• Changes in skin coloring
• Cloudy urine
• Diarrhea
• Difficulty with moving
• General feeling of discomfort or illness
• Hair loss, thinning of hair
• Muscle pain or stiffness
• Pain in the joints
• Sleeplessness
• Toothache
• Trouble with sleeping
• Unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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