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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of trandolapril in the pediatric population. Safety and efficacy have not been established .
Geriatric
Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of trandolapril in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems, which may require caution in patients receiving trandolapril .
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| 1st Trimester | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
| 2nd Trimester | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
| 3rd Trimester | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amiloride
- Azathioprine
- Canrenoate
- Eplerenone
- Potassium
- Spironolactone
- Triamterene
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Alclofenac
- Aliskiren
- Apazone
- Azosemide
- Bemetizide
- Bendroflumethiazide
- Benoxaprofen
- Benzthiazide
- Bromfenac
- Bufexamac
- Bumetanide
- Bupivacaine
- Buthiazide
- Capsaicin
- Carprofen
- Celecoxib
- Chlorothiazide
- Chlorthalidone
- Clometacin
- Clonixin
- Clopamide
- Cyclopenthiazide
- Cyclothiazide
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Ethacrynic Acid
- Etodolac
- Etofenamate
- Felbinac
- Fenbufen
- Fenoprofen
- Fentiazac
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Furosemide
- Gold Sodium Thiomalate
- Hydrochlorothiazide
- Hydroflumethiazide
- Ibuprofen
- Indapamide
- Indomethacin
- Indoprofen
- Isoxicam
- Ketoprofen
- Ketorolac
- Lithium
- Lornoxicam
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Methyclothiazide
- Metolazone
- Nabumetone
- Naproxen
- Niflumic Acid
- Nimesulide
- Oxaprozin
- Oxyphenbutazone
- Phenylbutazone
- Pirazolac
- Piretanide
- Piroxicam
- Pirprofen
- Polythiazide
- Propyphenazone
- Proquazone
- Quinethazone
- Rofecoxib
- Sulindac
- Suprofen
- Tenidap
- Tenoxicam
- Tiaprofenic Acid
- Tolmetin
- Torsemide
- Trichlormethiazide
- Valdecoxib
- Xipamide
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Angioedema, history of—Trandolapril may increase the risk of this condition occurring again .
- Dehydration or
- Diarrhea or
- Heart failure or
- Hyponatremia (low sodium in the blood) or
- Kidney disease—These conditions may cause the blood pressure to fall too low with trandolapril .
- Liver disease—The effects of trandolapril may be increased because of slower removal from the body.
