Vorinostat (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Anxiety
• Black, tarry stools
• Bleeding gums
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine or stools
• Body aches or pain
• Chest pain
• Chills
• Confusion
• Convulsions
• Cough
• Decreased urine
• Diarrhea
• Dizziness or lightheadedness
• Dry mouth
• Ear congestion
• Fainting
• Fast heartbeat
• Fever
• Headache
• Increased thirst
• Irregular heartbeat
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of appetite
• Loss of voice
• Lower back or side pain
• Mood changes
• Muscle pain or cramps
• Nasal congestion
• Nausea or vomiting
• No blood pressure
• No breathing
• No pulse
• Numbness or tingling in the face, arms, or legs
• Numbness or tingling in the hands, feet, or lips
• Pain, redness, or swelling in the arm or leg
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Rapid weight gain
• Runny nose
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sudden shortness of breath or troubled breathing
• Swollen glands
• Trouble speaking, thinking, or walking
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual drowsiness, dullness, or feeling of sluggishness
• Unusual tiredness or weakness

• Persistent non-healing sore
• Pink growth
• Reddish patch or irritated area
• Shiny bump
• White, yellow, or waxy scar-like area

• Chest discomfort
• General feeling of illness
• Hoarseness
• Indigestion
• Pain or discomfort in the arms, jaw, back, or neck
• Rapid, shallow breathing
• Severe nausea or vomiting
• Sneezing
• Stomach pain
• Sweating
• Tightness in the chest
• Vomiting of blood or material that looks like coffee grounds
• Wheezing
• Yellow skin and eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Change in taste
• Cracks in the skin
• Difficulty having a bowel movement (stool)
• Hair loss or thinning of the hair
• Itching skin
• Lack or loss of strength
• Loss of heat from the body
• Loss of taste
• Muscle spasm
• Red, swollen skin
• Scaly skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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