Antidepressant, Monoamine Oxidase (Mao) Inhibitor (Oral Route)

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Proper Use

Sometimes this medicine must be taken for several weeks before you begin to feel better. Your doctor should check your progress at regular visits, especially during the first few months of treatment, to make sure that this medicine is working properly and to check for unwanted effects.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

MAO inhibitors may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    For isocarboxazid
  • For oral dosage form (tablets):
    • For treatment of depression:
      • Adults—To start, 10 milligrams (mg) twice a day. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
      • Children younger than 16 years of age—Use and dose must be determined by the doctor.
    For phenelzine
  • For oral dosage form (tablets):
    • For treatment of depression:
      • Adults—Dose is based on your body weight. To start, the usual dose is 1 milligram (mg) per kilogram (kg) of body weight (0.45 mg per pound) a day. Your doctor may decrease or increase your dose as needed. However, the dose usually is not more than 90 mg a day.
      • Children younger than 16 years of age—Use and dose must be determined by the doctor.
      • Older adults—To start, 15 mg in the morning. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
    For tranylcypromine
  • For oral dosage form (tablets):
    • For treatment of depression:
      • Adults—To start, 30 milligrams (mg) a day. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
      • Children younger than 16 years of age—Use and dose must be determined by the doctor.
      • Older adults—To start, 2.5 to 5 mg a day. The doctor may increase your dose as needed. However, the dose usually is not more than 45 mg a day.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, take it as soon as possible. However, if it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions Before Using

DR602071

Portions of this document last updated:

Nov. 1, 2009

Source: Drug Information provided by: Micromedex

Copyright © 2009 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.


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