In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.
Dizziness or light-headedness, drowsiness, or signs of too much potassium loss may be more likely to occur in the elderly, who are more sensitive to the effects of methyldopa and hydrochlorothiazide.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Enalapril Maleate
- Ferric Ammonium Citrate
- Ibuprofen Lysine
- Magnesium Salicylate
- Mefenamic Acid
- Salicylic Acid
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Angina (chest pain)—Methyldopa may worsen the condition.
- Type 2 diabetes mellitus—Hydrochlorothiazide may change the amount of diabetes medicine needed.
- Gout (history of)—Hydrochlorothiazide may increase the amount of uric acid in the blood, which can lead to gout.
- High cholesterol—Hydrochlorothiazide may raise cholesterol levels.
- Kidney disease—Effects of methyldopa and hydrochlorothiazide may be increased because of slower removal from the body. If severe, hydrochlorothiazide may not work.
- Liver disease—Effects of methyldopa may be increased because of slower removal from the body. If hydrochlorothiazide causes loss of too much water from the body, liver disease can become much worse.
- Lupus erythematosus (history of)—Hydrochlorothiazide may worsen the condition.
- Mental depression (history of)—Methyldopa can cause mental depression
- Pancreatitis (inflammation of the pancreas)
- Parkinson's disease—Methyldopa may worsen the condition.
- Pheochromocytoma—Methyldopa may interfere with tests for the condition. In addition, there have been reports of increased blood pressure.