Diflunisal (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Stomach cramps or pain

• Back or leg pains
• Bleeding gums
• Blistering, peeling, loosening of skin
• Bloody or black, tarry stools
• Bloody or cloudy urine
• Blurred or loss of vision
• Burning feeling in chest or stomach
• Burning while urinating
• Clay-colored stools
• Constipation
• Cough or hoarseness
• Cracks in the skin
• Dark-colored urine
• Diarrhea
• Difficult or painful urination
• Difficulty breathing
• Difficulty swallowing
• Disturbed color perception
• Dizziness
• Double vision
• Facial swelling
• Fast heartbeat
• Feeling of warmth
• Fever with or without chills
• Flu-like symptoms
• General body swelling
• General feeling of tiredness or weakness
• Greatly decreased frequency of urination or amount of urine
• Halos around lights
• Headache
• Hives
• Increased blood pressure
• Increased thirst
• Indigestion
• Itching
• Joint or muscle pain
• Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
• Light-colored stools
• Liver function abnormalities
• Loss of appetite
• Loss of heat from the body
• Lower back or side pain
• Muscle aches, pains, or weakness
• Nausea or vomiting
• Night blindness
• Noisy breathing
• Nosebleeds
• Overbright appearance of lights
• Pale skin
• Pinpoint red spots on skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• Red, irritated eyes
• Redness of the face, neck, arms and occasionally, upper chest
• Red skin lesions, often with a purple center
• Red, swollen skin
• Scaly skin
• Severe or continuing stomach pain
• Shortness of breath
• Skin rash
• Sores, ulcers, or white spots in mouth or on lips
• Sore throat
• Stomach upset
• Swelling of face, fingers, feet or lower legs
• Swollen lymph nodes
• Tenderness in stomach area
• Tightness in chest
• Troubled breathing
• Tunnel vision
• Unpleasant breath odor
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Upper right abdominal pain
• Vomiting of blood or material that looks like coffee grounds
• Weight gain
• Wheezing
• Yellow eyes or skin

• Change in consciousness
• Confusion about identity, place, and time
• Continuing ringing or buzzing or other unexplained noise in ears
• Decreased awareness or responsiveness
• Deep or fast breathing with dizziness
• Fast, pounding, or irregular heartbeat or pulse
• Hearing loss
• Loss of consciousness
• Numbness of feet, hands, and around mouth
• Severe sleepiness
• Sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Heartburn
• Indigestion
• Stomach discomfort or upset

• Bloated, full feeling
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Discouragement
• Dry mucous membranes
• Excess air or gas in stomach or intestines
• Feeling of constant movement of self or surroundings
• Feeling sad or empty
• Increased sensitivity of skin to sunlight
• Irritability
• Lack or loss of strength
• Lightheadedness
• Loss of interest or pleasure
• Mood or mental changes
• Nervousness
• Passing gas
• Seeing, hearing, or feeling things that are not there
• Sensation of spinning
• Severe sunburn
• Sleeplessness
• Swelling or inflammation of the mouth
• Tiredness
• Trouble concentrating
• Trouble sleeping
• Unable to sleep
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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