Oxaprozin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Skin rash

• Bloating
• Bloody or black, tarry stools
• Burning upper abdominal pain
• Burning while urinating
• Cloudy urine
• Constipation
• Decrease in urine output or decrease in urine-concentrating ability
• Diarrhea
• Difficult or painful urination
• Frequent urination
• Headache
• Heartburn
• Indigestion
• Itching skin
• Loss of appetite
• Nausea or vomiting
• Pale skin
• Severe abdominal pain, cramping, or burning
• Severe and continuing nausea
• Swelling
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of blood or material that looks like coffee grounds
• Weight loss

• Agitation
• Bleeding gums
• Blistering, peeling, loosening of skin
• Blurred vision
• Body aches or pain
• Burning feeling in chest or stomach
• Changes in blood pressure
• Chest pain
• Clay-colored stools
• Coma
• Confusion
• Cough or hoarseness
• Cracks in the skin
• Dark urine
• Depression
• Difficult or labored breathing
• Difficulty swallowing
• Dilated neck veins
• Dizziness
• Ear congestion
• Extreme fatigue
• Fainting
• Feeling of discomfort
• Fever or chills
• Fluid-filled skin blisters
• High fever
• Hives or welts
• Hostility
• Increased sensitivity of skin to sunlight
• Increased thirst
• Increased volume of pale, dilute urine
• Inflammation of joints
• Irregular, fast or slow, or shallow breathing
• Irritability
• Joint or muscle pain
• Large, flat, blue or purplish patches in the skin
• Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Lethargy
• Light-colored stools
• Lightheadedness
• Loss of heat from the body
• Loss of voice
• Lower back or side pain
• Muscle aches
• Muscle twitching
• Nasal congestion
• Nervousness
• Noisy breathing
• Pain or burning in throat
• Pain or tenderness around eyes and cheekbones
• Pale or blue lips, fingernails, or skin
• Pinpoint red or purple spots on skin
• Pounding in the ears
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rapid weight gain
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Redness or other discoloration of skin
• Redness, swelling, or soreness of tongue
• Scaly skin
• Seizures
• Severe sunburn
• Shortness of breath
• Skin thinness
• Slow, fast, irregular, pounding, or racing heartbeat or pulse
• Sneezing
• Sore throat
• Sores, ulcers, or white spots on lips or tongue or inside the mouth
• Stomach upset
• Stuffy or runny nose
• Stupor
• Swelling of face, fingers, feet, or lower legs
• Swelling or inflammation of the mouth
• Swollen lymph glands
• Tenderness in stomach area
• Tightness in chest
• Unpleasant breath odor
• Upper right abdominal pain
• Wheezing
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Stomach discomfort

• Continuing ringing or buzzing or other unexplained noise in ears
• Excess air or gas in stomach or intestines
• Hearing loss
• Passing gas
• Relaxed and calm
• Sleepiness or unusual drowsiness
• Trouble sleeping

• Anxiety
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Burning, dry, or itching eyes
• Change in taste
• Decreased hearing
• Discharge, excessive tearing
• Dry mouth
• Feeling of constant movement of self or surroundings
• General feeling of discomfort or illness
• Lack or loss of strength
• Redness, pain, swelling of eye, eyelid, or inner lining of eyelid
• Sensation of spinning
• Shakiness in legs, arms, hands, feet
• Sleeplessness
• Trembling or shaking of hands or feet
• Unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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