Alteplase, Recombinant (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Bleeding from puncture sites and wounds
  • Bleeding gums
  • Coughing up blood
  • Difficulty with breathing or swallowing
  • Dizziness
  • Headache
  • Increased menstrual flow or vaginal bleeding
  • Nosebleeds
  • Paralysis
  • Prolonged bleeding from cuts
  • Red or black, tarry stools
  • Red or dark brown urine
  • Shortness of breath
Rare
  • Chills
  • Confusion
  • Fainting
  • Fast heartbeat
  • Fever
  • Lightheadedness
  • Pain in chest, groin, or legs, especially the calves
  • Pain, redness, or swelling in arm or leg
  • Rapid, shallow breathing
  • Severe, sudden headache
  • Slurred speech
  • Sudden loss of coordination
  • Sudden, severe weakness or numbness in arm or leg
  • Sudden, unexplained shortness of breath
  • Vision changes
Incidence not determined
  • Anxiety
  • Blue lips and fingernails
  • Blue or pale skin
  • Blurred vision
  • Chest pain or discomfort
  • Chest pain, possibly moving to the left arm, neck, or shoulder
  • Convulsions
  • Cool, sweaty skin
  • Cough
  • Coughing that sometimes produces a pink frothy sputum
  • Decreased urine output
  • Dilated neck veins
  • Extreme fatigue
  • Hives or welts
  • Hoarseness
  • Increased sweating
  • Itching
  • Large, hive-like swelling on mouth, lips, or tongue
  • Loss of bladder control
  • Low blood pressure or pulse
  • Muscle spasm or jerking of all extremities
  • Nausea or vomiting
  • Pain or discomfort in arms, jaw, back, or neck
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Redness of skin
  • Skin rash
  • Slow or irregular breathing or heartbeat
  • Sudden loss of consciousness
  • Sweating
  • Swelling of face, fingers, feet, lower legs, or ankles
  • Tightness in chest
  • Troubled breathing
  • Unconsciousness
  • Unusual tiredness or weakness
  • Weight gain
  • Wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions
DR602391 Portions of this document last updated: Nov. 1, 2011

Source: Drug Information provided by: Micromedex

Copyright © 2013 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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