Sunitinib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bleeding gums
• Bloating or swelling of the face, arms, hands, fingers, lower legs, or feet
• Blurred vision
• Chest pain
• Chills
• Confusion
• Coughing up blood
• Cracked lips
• Decreased urination
• Decreased urine output
• Diarrhea
• Difficulty with breathing or swallowing
• Dilated neck veins
• Dizziness
• Dry mouth
• Extreme fatigue
• Fainting
• Fast, slow, or irregular heartbeat
• Fever
• Headache
• Increase in heart rate
• Increased menstrual flow or vaginal bleeding
• Irregular breathing
• Labored breathing
• Lightheadedness
• Nervousness
• Nosebleeds
• Paralysis
• Pounding in the ears
• Prolonged bleeding from cuts
• Rapid breathing
• Rapid weight gain
• Red or black, tarry stools
• Red or dark brown urine
• Shortness of breath
• Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• Sunken eyes
• Swelling or inflammation of the mouth
• Thirst
• Tightness in the chest
• Tingling of the hands or feet
• Troubled breathing
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Wheezing
• Wrinkled skin
• Yellow eyes or skin

• Bleeding from the rectum
• Bleeding from wounds
• Constipation
• Depressed mood
• Dry skin and hair
• Feeling cold
• Hair loss
• Hoarseness or husky voice
• Indigestion
• Loss of appetite
• Muscle cramps and stiffness
• Nausea
• Pain in the chest, groin, or legs, especially the calves
• Pain in the stomach, side, or abdomen, possibly radiating to the back
• Severe stomach pain
• Severe, sudden headache
• Slurred speech
• Sudden loss of coordination
• Sudden, severe weakness or numbness in the arm or leg
• Sudden, unexplained shortness of breath
• Vision changes
• Vomiting
• Vomiting of blood or material that looks like coffee grounds

• Back pain
• Chest discomfort
• Cloudy or bloody urine
• Convulsions
• Darkening of the skin
• Drowsiness
• General feeling of tiredness or weakness
• Irregular or slow heart rate
• Light-colored stools
• Mental depression
• Skin rash
• Stomach pain, continuing

• Cough
• Coughing up blood
• Dark-colored urine
• Heavy jaw feeling
• Increased thirst
• Joint pain, stiffness, or swelling
• Loosening of a tooth
• Lower back or side pain
• Muscle cramps or spasms
• Muscular pain, tenderness, wasting, or weakness
• Pain, swelling, or numbness in the mouth or jaw
• Painful or difficult urination
• Pale skin
• Sore throat
• Sudden, severe chest pain
• Unusual bleeding or bruising
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Blistering, peeling, redness, or swelling of the palms, hands, or bottoms of the feet
• Change in color of the treated skin
• Change in taste
• Difficulty with moving
• Discouragement
• Excess air or gas in the stomach or intestines
• Feeling sad or empty
• Full feeling
• Hair color changes
• Hair loss or thinning of the hair
• Heartburn
• Irritability
• Joint pain
• Lack of appetite
• Lack or loss of strength
• Loss of interest or pleasure
• Muscle aches or pains
• Numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
• Pain or burning in the throat
• Passing gas
• Sleeplessness
• Stomach discomfort, upset, or pain
• Swollen joints
• Trouble concentrating
• Trouble sleeping
• Unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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