Temsirolimus (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bladder pain
• Bloody nose
• Bloody or cloudy urine
• Body aches or pain
• Chest pain
• Congestion
• Cough or hoarseness
• Cracked lips
• Diarrhea
• Difficult or labored breathing
• Difficult, burning, or painful urination
• Difficulty with swallowing
• Dryness or soreness of the throat
• Fever or chills
• Frequent urge to urinate
• Headache
• Lack or loss of strength
• Lower back or side pain
• Shortness of breath
• Sneezing
• Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• Stomach pain
• Stuffy or runny nose
• Swelling of the hands, ankles, feet, or lower legs
• Swelling or puffiness of the face
• Tender, swollen glands in the neck
• Tightness in the chest
• Voice changes
• Vomiting
• Wheezing

• Blistering, peeling, or loosening of the skin
• Convulsions
• Dark-colored urine
• Itching
• Joint or muscle pain
• Muscle cramps or spasms
• Muscle stiffness
• Pain or redness at the injection site
• Pale skin at injection site
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Blemishes on the skin
• Change in taste
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Discoloration of the fingernails or toenails
• Dry skin
• Loss of appetite
• Loss of taste
• Nausea
• Pain in the joints
• Pimples
• Rash
• Sleeplessness
• Swollen joints
• Trouble with sleeping
• Unable to sleep
• Weight loss

• Discouragement
• Feeling sad or empty
• Irritability
• Loss of interest or pleasure
• Tiredness
• Trouble concentrating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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