Lepirudin (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Bleeding from puncture sites and wounds
  • Blood in the urine
  • Bloody or black, tarry stools
  • Collection of blood under the skin
  • Constipation
  • Dark urine
  • Deep, dark purple bruise
  • Fever with or without chills
  • Itching, pain, redness, or swelling
  • Light-colored stools
  • Loss of appetite
  • Nausea and vomiting
  • Pale skin
  • Severe stomach pain
  • Troubled breathing with exertion
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomiting of blood or material that looks like coffee grounds
  • Yellow eyes or skin
Less common
  • Bloody nose
  • Chest pain or discomfort
  • Cloudy urine
  • Confusion
  • Cough or hoarseness
  • Decrease in urine output
  • Difficult or labored breathing
  • Dilated neck veins
  • Dizziness
  • Extreme fatigue
  • Fainting
  • Fast, slow, or irregular heartbeat
  • Headache, sudden and severe
  • Irregular breathing
  • Lightheadedness
  • Lower back or side pain
  • Noisy breathing
  • Painful or difficult urination
  • Rapid, shallow breathing
  • Shortness of breath
  • Skin rash, hives, itching, or redness
  • Sneezing
  • Sore throat
  • Swelling of the face, fingers, feet, or lower legs
  • Tightness in the chest
  • Troubled breathing
  • Vaginal bleeding
  • Weakness
  • Weight gain
  • Wheezing
Rare
  • Difficulty swallowing
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Tightness or swelling of the neck

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions
DR602463 Portions of this document last updated: July 1, 2012

Source: Drug Information provided by: Micromedex

Copyright © 2013 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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