Ambrisentan (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Rapid weight gain
• Tingling of the hands or feet
• Unusual weight gain or loss

• Cough
• Fast, irregular, pounding, or racing heartbeat or pulse
• Fever
• Headache
• Muscle aches
• Pain or tenderness around the eyes and cheekbones
• Sore throat
• Stuffy or runny nose
• Tightness of the chest
• Trouble breathing
• Unusual tiredness or weakness

• Abdominal or stomach pain or tenderness
• Chest pain
• Clay colored stools
• Dark urine
• Decrease in the amount of urine
• Decreased appetite
• Dilated neck veins
• Extreme fatigue
• Irregular breathing
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of appetite
• Nausea and vomiting
• Noisy, rattling breathing
• Pale skin
• Skin rash
• Troubled breathing at rest
• Troubled breathing with exertion
• Yellow skin or eyes

Get emergency help immediately if any of the following symptoms of overdose occur:

• Blurred vision
• Confusion
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty having a bowel movement (stool)
• Feeling of warmth
• Redness of the face, neck, arms, and occasionally, upper chest

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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