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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of propranolol and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established .
Geriatric
Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of propranolol and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving propranolol and hydrochlorothiazide combination .
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breastfeeding
Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Dofetilide
- Thioridazine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acetyldigoxin
- Albuterol
- Amiodarone
- Arformoterol
- Arsenic Trioxide
- Bambuterol
- Bitolterol
- Broxaterol
- Clenbuterol
- Clonidine
- Colterol
- Deslanoside
- Diatrizoate
- Digitalis
- Digitoxin
- Digoxin
- Diltiazem
- Dronedarone
- Droperidol
- Epinephrine
- Fenoldopam
- Fenoterol
- Fentanyl
- Flecainide
- Formoterol
- Haloperidol
- Hexoprenaline
- Isoetharine
- Ketanserin
- Levalbuterol
- Levomethadyl
- Lidocaine
- Lithium
- Mefloquine
- Metaproterenol
- Metildigoxin
- Ouabain
- Pirbuterol
- Procaterol
- Proscillaridin
- Reproterol
- Rimiterol
- Ritodrine
- Salmeterol
- Sotalol
- Terbutaline
- Tretoquinol
- Tulobuterol
- Verapamil
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acarbose
- Aceclofenac
- Acemetacin
- Acetohexamide
- Alacepril
- Alclofenac
- Alfuzosin
- Aluminum Carbonate, Basic
- Aluminum Hydroxide
- Aluminum Phosphate
- Amlodipine
- Apazone
- Arbutamine
- Benazepril
- Benfluorex
- Benoxaprofen
- Bepridil
- Bromfenac
- Bufexamac
- Bunazosin
- Calcium Carbonate
- Captopril
- Carbamazepine
- Carprofen
- Celecoxib
- Chlorpromazine
- Chlorpropamide
- Cholestyramine
- Cilazapril
- Cimetidine
- Clometacin
- Clonixin
- Cyclophosphamide
- Delapril
- Dexketoprofen
- Diclofenac
- Diflunisal
- Digoxin
- Dihydroergotamine
- Dihydroxyaluminum Aminoacetate
- Dihydroxyaluminum Sodium Carbonate
- Dipyrone
- Disopyramide
- Doxazosin
- Droxicam
- Enalaprilat
- Enalapril Maleate
- Ergotamine
- Etodolac
- Etofenamate
- Felbinac
- Felodipine
- Fenbufen
- Fenoprofen
- Fentiazac
- Flecainide
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Fluvoxamine
- Fosinopril
- Ginkgo
- Gliclazide
- Glimepiride
- Glipizide
- Gliquidone
- Glyburide
- Gossypol
- Guar Gum
- Guggul
- Ibuprofen
- Imidapril
- Indomethacin
- Indoprofen
- Insulin
- Insulin Aspart, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Isoxicam
- Ketoprofen
- Ketorolac
- Lacidipine
- Lercanidipine
- Licorice
- Lisinopril
- Lornoxicam
- Magaldrate
- Manidipine
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Metformin
- Mibefradil
- Miglitol
- Moexipril
- Moxisylyte
- Nabumetone
- Naproxen
- Nicardipine
- Nifedipine
- Niflumic Acid
- Nilvadipine
- Nimesulide
- Nimodipine
- Nisoldipine
- Nitrendipine
- Oxaprozin
- Oxyphenbutazone
- Pentopril
- Perindopril
- Phenoxybenzamine
- Phentolamine
- Phenylbutazone
- Phenylephrine
- Piperine
- Pirazolac
- Piroxicam
- Pirprofen
- Pranidipine
- Prazosin
- Propoxyphene
- Propyphenazone
- Proquazone
- Quinapril
- Quinidine
- Ramipril
- Repaglinide
- Rifapentine
- Rizatriptan
- Rofecoxib
- Sertraline
- Spirapril
- St John's Wort
- Sulindac
- Suprofen
- Tamsulosin
- Temocapril
- Tenidap
- Tenoxicam
- Terazosin
- Tiaprofenic Acid
- Ticrynafen
- Tolazamide
- Tolbutamide
- Tolmetin
- Topiramate
- Trandolapril
- Trimazosin
- Troglitazone
- Tubocurarine
- Urapidil
- Zileuton
- Zofenopril
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Angina (severe chest pain)—May provoke chest pain if stopped too quickly .
- Anuria (not able to form urine) or
- Asthma or
- Bradycardia (slow heartbeat) or
- Heart block or
- Heart failure—Should not use in patients with these conditions .
- Diabetes or
- Hyperthyroidism (overactive thyroid) or
- Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
- Gout or
- Hyperuricemia (high uric acid in the blood) or
- Hypochloremia (low chloride in the blood) or
- Hypokalemia (low potassium in the blood) or
- Hyponatremia (low sodium in the blood) or
- Parathyroid disease or
- Systemic lupus erythematosus—Use with caution. This medicine may make these conditions worse .
- Kidney disease, severe or
- Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .
- Lung disease (e.g., bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .
- Sympathectomy—Use with caution. The effects of this medicine may be increased .
- Wolff-Parkinson-White syndrome (rare heart condition)—May cause very slow heartbeat in patients with this condition .
