Propranolol and Hydrochlorothiazide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain, usually after eating a meal
• Abdominal or stomach tenderness
• Black, tarry stools
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Bloating
• Blood in the urine
• Bloody nose
• Bloody stools
• Blurred or loss of vision
• Body aches or pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Clay-colored stools
• Cold sweats
• Confusion about identity, place, and time
• Congestion
• Constipation
• Cough
• Coughing up blood
• Cracks in the skin
• Crying
• Darkened urine
• Decreased awareness or responsiveness
• Decreased urine output
• Depersonalization
• Diarrhea
• Difficulty with breathing or swallowing
• Dilated neck veins
• Disturbed color perception
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Double vision
• Dry mouth
• Dryness or soreness of the throat
• Dysphoria
• Euphoria
• Extreme fatigue
• Fast, pounding, slow, or irregular heartbeat
• Fever or chills
• Flushing or redness of the skin
• Fruit-like breath odor
• General feeling of discomfort or illness
• General feeling of tiredness or weakness
• Hair loss
• Halos around lights
• Headaches
• Heavier menstrual periods
• Hives or welts
• Hoarseness
• Increased hunger
• Increased sensitivity of the skin to sunlight
• Increased thirst
• Increased urination
• Indigestion
• Irregular breathing
• Irregular heartbeat
• Itching
• Joint pain, stiffness, or swelling
• Lightheadedness, dizziness, or fainting
• Loss of appetite
• Loss of heat from the body
• Loss of strength or energy
• Lower back or side pain
• Mental depression
• Mimicry of speech or movements
• Muscle pain or weakness
• Mutism
• Nausea or vomiting
• Negativism
• Night blindness
• Noisy breathing
• Overbright appearance of lights
• Painful or difficult urination
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Paleness or cold feeling in the fingertips and toes
• Paranoia
• Peculiar postures or movements, mannerisms or grimacing
• Pinpoint red or purple spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Quick to react or overreact emotionally
• Rapidly changing moods
• Rectal bleeding
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Red, swollen skin
• Reddening of the skin, especially around the ears
• Runny nose
• Scaly skin
• Seeing, hearing, or feeling things that are not there
• Severe sleepiness
• Severe sunburn
• Short-term memory loss
• Shortness of breath
• Skin irritation or rash, including rash that looks like psoriasis
• Sleeplessness
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sugar in the urine
• Sweating
• Swelling of the eyes, face, or inside of the nose
• Swelling of the fingers, feet, or lower legs
• Tender, swollen, or painful glands in the neck
• Tenderness of salivary glands
• Tenderness, burning, or peeling of the skin
• Thickening of bronchial secretions
• Tightness in the chest
• Tingling or pain in the fingers or toes when exposed to cold
• Trouble with sleeping
• Trouble with swallowing
• Troubled breathing
• Tunnel vision
• Unable to sleep
• Unpleasant breath odor
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight loss
• Unusually warm skin
• Voice changes
• Vomiting of blood
• Weight gain
• Wheezing
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Change in consciousness
• Decreased urination
• Fast, slow, or shallow breathing
• Gas
• Heartburn
• Increase in heart rate
• Increased sweating
• Indigestion
• Loss of consciousness
• Low blood pressure
• Muscle cramps
• Pale or blue lips, fingernails, or skin
• Rapid breathing
• Seizures
• Sunken eyes
• Unusual drowsiness, dullness, or feeling of sluggishness
• Unusual paleness
• Weakness and heaviness of the legs
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Decreased interest in sexual intercourse
• Dry eyes
• Feeling of constant movement of self or surroundings
• Inability to have or keep an erection
• Loss in sexual ability, desire, drive, or performance
• Muscle spasm
• Pain of the penis on erection
• Pain or discomfort in the chest, upper stomach, or throat
• Restlessness
• Sensation of spinning
• Stomach cramps
• Thinning of the hair
• Vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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