Ixabepilone (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Black, tarry stools
• Body aches or pain
• Burning, numbness, tingling, or painful sensations
• Burning pain on urination
• Chest pain
• Chills
• Cough
• Difficult or labored breathing
• Ear congestion
• Fever
• Headache
• Loss of voice
• Lower back or side pain
• Nasal congestion
• Painful or difficult urination
• Pale skin
• Red, swelling, or painful skin
• Runny nose
• Scaling of the skin on the hands and feet
• Shortness of breath
• Sneezing
• Sore throat
• Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• Swelling of the hands, ankles, feet, or lower legs
• Swollen glands
• Tightness in the chest
• Tingling of the hands and feet
• Troubled breathing with exertion
• Ulceration of the skin
• Unsteadiness or awkwardness
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain
• Weakness in the arms, hands, legs, or feet
• Wheezing

• Bleeding gums
• Blood in the urine or stools
• Confusion
• Decreased urination
• Dizziness
• Dry mouth
• Fainting
• Fast heartbeat
• Hives
• Hoarseness
• Increase in heart rate
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Lightheadedness
• Pinpoint red spots on the skin
• Rapid breathing
• Rash
• Sunken eyes
• Swelling of the eyelids, face, or lips
• Thirst
• Trouble with swallowing
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bad, unusual, or unpleasant (after) taste
• Bone pain
• Change in taste
• Cracked lips
• Diarrhea
• Difficulty having a bowel movement (stool)
• Discoloration of the fingernails or toenails
• Feeling of warmth
• Hair loss or thinning of the hair
• Heartburn
• Lack or loss of strength
• Loss of appetite
• Nausea
• Redness of the face, neck, arms, and occasionally, upper chest
• Stomach pain
• Sudden sweating
• Swelling or inflammation of the mouth
• Vomiting
• Weight loss

• Darkening of the skin
• Flaking and falling off of the skin
• Sleeplessness
• Trouble with sleeping
• Unable to sleep
• Watering of the eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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