Itraconazole (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Convulsions
• Decreased urine
• Dry mouth
• Fever
• Increased thirst
• Irregular heartbeat
• Loss of appetite
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Numbness or tingling in the hands, feet, or lips
• Shortness of breath
• Unusual tiredness or weakness

• Abdominal or stomach cramps
• Abdominal or stomach pain
• Blurred vision
• Chest pain
• Chills
• Clay-colored stools
• Cloudy urine
• Cold sweats
• Confusion
• Cough
• Dark urine
• Decrease in urine output or decrease in urine-concentrating ability
• Diarrhea
• Difficult or labored breathing
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Drowsiness
• Feeling unusually cold
• Headache
• Itching
• Light-colored stools
• Mental changes
• Muscle cramps in the hands, arms, feet, legs, or face
• Muscle spasms (tetany) or twitching
• Nervousness
• Noisy, rattling breathing
• Numbness and tingling around the mouth or fingertips
• Pounding in the ears
• Rash
• Shivering
• Slow, fast, or pounding heartbeat or pulse
• Sneezing
• Sore throat
• Sweating
• Swelling of the fingers, hands, feet, or lower legs
• Tightness in the chest
• Trembling
• Troubled breathing at rest
• Unpleasant breath odor
• Vomiting of blood
• Weight gain
• Wheezing
• Yellow eyes or skin

• Abdominal or stomach tenderness
• Black, tarry stools
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine or stools
• Blue lips and fingernails
• Burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
• Continuing ringing or buzzing or other unexplained noise in the ears
• Coughing that sometimes produces a pink frothy sputum
• Cracks in the skin
• Decreased appetite
• Difficulty with swallowing
• Dilated neck veins
• Disturbed color perception
• Double vision
• Extreme fatigue
• Fast or irregular breathing
• Feeling of discomfort
• General feeling of tiredness or weakness
• Halos around lights
• Hearing loss
• Hives or welts
• Inflammation of the joints
• Joint pain
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of heat from the body
• Loss of vision
• Lower back or side pain
• Night blindness
• Overbright appearance of lights
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rapid weight gain
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Red, swollen skin
• Scaly skin
• Sores, ulcers, or white spots on the lips or in the mouth
• Stomach pain, continuing
• Swollen lymph glands
• Tingling of the hands or feet
• Tunnel vision
• Unsteadiness or awkwardness
• Unusual bleeding or bruising
• Unusual weight gain or loss
• Upper right abdominal or stomach pain
• Weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Decreased interest in sexual intercourse
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Discouragement
• Feeling of constant movement of self or surroundings
• Feeling sad or empty
• Inability to have or keep an erection
• Indigestion
• Irritability
• Loss in sexual ability, desire, drive, or performance
• Loss of interest or pleasure
• Muscle aching or stiffness
• Pain or tenderness around the eyes and cheekbones
• Passing of gas
• Sensation of spinning
• Sleepiness or unusual drowsiness
• Soreness of the skin
• Stomach fullness or discomfort
• Stuffy or runny nose
• Swollen joints
• Tiredness
• Trouble concentrating
• Trouble sleeping

• Acid or sour stomach
• Belching
• Change in taste
• Hair loss or thinning of the hair
• Heartburn
• Increased need to urinate
• Increased sensitivity of the eyes to sunlight
• Increased sensitivity of the skin to sunlight
• Loss of bladder control
• Loss of taste
• Menstrual changes
• Passing urine more often
• Redness or other discoloration of the skin
• Severe sunburn
• Stomach fullness, discomfort, or upset

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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