Spironolactone and Hydrochlorothiazide (Oral Route)

Free

E-newsletter

Subscribe to Housecall

Our weekly general interest
e-newsletter keeps you up to date on a wide variety of health topics.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach cramping, burning, or tenderness
• Back or leg pains
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Bloating
• Bloody or black, tarry stools
• Bloody or cloudy urine
• Blue lips and fingernails
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain
• Chills
• Clay-colored stools
• Clear or bloody discharge from the nipple
• Cloudy urine
• Confusion
• Constipation
• Cough or hoarseness
• Coughing that sometimes produces a pink frothy sputum
• Coughing up blood
• Dark urine
• Decrease in urine-concentrating ability
• Decreased appetite
• Diarrhea
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Difficulty with swallowing
• Dimpling of the breast skin
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Dry mouth
• Fast or irregular heartbeat
• Fever with or without chills
• Flushed, dry skin
• Fruit-like breath odor
• General body swelling
• General feeling of discomfort or illness
• Greatly decreased frequency of urination or amount of urine
• Headache
• Heartburn
• Hives or welts
• Increased blood pressure
• Increased hunger
• Increased sweating
• Increased thirst
• Increased urination
• Indigestion
• Inverted nipple
• Joint pain, stiffness, or swelling
• Loss of appetite
• Lower back or side pain
• Lump in the breast or under the arm
• Muscle cramps or pain
• Nausea and vomiting
• Nosebleeds
• Numbness, tingling, pain, or weakness in the hands, feet, or lips
• Painful or difficult urination
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Pale skin
• Persistent crusting or scaling of the nipple
• Pinpoint red or purple spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Red, irritated eyes
• Redness or swelling of the breast
• Redness, soreness, or itching skin
• Seizures
• Severe stomach pain
• Shakiness and unsteady walk
• Shortness of breath
• Skin rash
• Sore on the skin of the breast that does not heal
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sugar in the urine
• Swelling in the legs and ankles
• Swelling of the face, hands, fingers, feet, or lower legs
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Thickening of bronchial secretions
• Tightness in the chest
• Trembling
• Troubled breathing
• Unpleasant breath odor
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight loss
• Vomiting of blood or material that looks like coffee grounds
• Weakness and heaviness of the legs
• Weight gain
• Wheezing
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Difficulty with sleeping
• Disorientation
• Drowsiness to profound coma
• Hallucination
• Lethargy
• Lightheadedness
• Mood or other mental changes
• Rash with flat lesions or small raised lesions on the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Absent, missed, or irregular menstrual periods
• Bleeding after menopause
• Burning feeling in the chest or stomach
• Discoloration of the skin
• Feeling of constant movement of self or surroundings
• Inability to have or keep an erection
• Increased sensitivity of the skin to sunlight
• Muscle spasm
• Restlessness
• Sensation of spinning
• Severe sunburn
• Stomach upset
• Stopping of menstrual bleeding
• Swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Copyright © 2013 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.