Aliskiren and Hydrochlorothiazide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Chills
• Cough
• Diarrhea
• Fever
• General feeling of discomfort or illness
• Headache
• Joint pain
• Loss of appetite
• Muscle aches and pains
• Nausea
• Runny nose
• Shivering
• Sore throat
• Sweating
• Trouble sleeping
• Unusual tiredness or weakness
• Vomiting

• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Hives
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur:

• Coma
• Confusion
• Decreased urine output
• Drowsiness
• Dry mouth
• Fainting
• Increase in heart rate
• Increased thirst
• Irregular heartbeat
• Irritability
• Lightheadedness
• Muscle cramps
• Numbness, tingling, pain, or weakness in the hands or feet
• Rapid breathing
• Seizures
• Sunken eyes
• Swelling of the face, ankles, or hands
• Trembling
• Weak pulse
• Weakness and heaviness of the legs
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty with moving
• Feeling of constant movement of self or surroundings
• Lack or loss of strength
• Muscle stiffness
• Sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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