Spironolactone (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach cramping, burning, or tenderness
• Bloody or black, tarry stools
• Bloody urine
• Chills
• Clay-colored stools
• Clear or bloody discharge from the nipple
• Cloudy urine
• Constipation
• Cough or hoarseness
• Dark urine
• Decrease in urine output or decrease in urine-concentrating ability
• Diarrhea
• Difficulty with swallowing
• Dimpling of the breast skin
• Dizziness
• Fast heartbeat
• Fever with or without chills
• General feeling of tiredness or weakness
• Headache
• Heartburn
• Hives
• Increased thirst
• Indigestion
• Inverted nipple
• Itching
• Loss of appetite
• Lower back or side pain
• Lump in the breast or under the arm
• Nausea and vomiting
• Painful or difficult urination
• Persistent crusting or scaling of the nipple
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Redness or swelling of the breast
• Severe stomach pain
• Shakiness and unsteady walk
• Skin rash
• Sore on the skin of the breast that does not heal
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the face, fingers, feet, or lower legs
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Tightness in the chest
• Troubled breathing
• Unpleasant breath odor
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of blood or material that looks like coffee grounds
• Weight gain
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Coma
• Confusion
• Convulsions
• Drowsiness
• Irregular heartbeat
• Muscle pain or cramps
• Nervousness
• Numbness or tingling in the hands, feet, or lips
• Rash with flat lesions or small raised lesions on the skin
• Reddened skin
• Swelling of the ankles or hands
• Weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Burning feeling in the chest or stomach
• Sores, welting, or blisters
• Stomach upset
• Swelling of the breasts or breast soreness in both females and males
• Unusual dullness or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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