Desvenlafaxine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Dizziness
• Fast, pounding, or irregular heartbeat or pulse
• Headache
• Numbness or tingling in the arms or legs
• Shakiness in the legs, arms, hands, or feet
• Trembling or shaking of the hands or feet
• Trouble thinking, speaking, or walking
• Weakness

• Actions that are out of control
• Bigger, dilated, or enlarged pupils (black part of the eye)
• Blood in stool
• Blood in urine
• Chest tightness
• Convulsions (seizures)
• Fever
• Hives
• Hoarseness
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of bladder control
• Muscle spasm or jerking of all extremities
• Nose bleeds
• Rash
• Redness of skin
• Shortness of breath
• Sudden loss of consciousness
• Swelling of the eyelids, face, lips, hands, or feet
• Talking, feeling, and acting with excitement
• Troubled breathing or swallowing
• Unusual bruising
• Vomiting blood
• Wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

• Abdominal or stomach pain
• Bloating of the abdomen or stomach
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Confusion
• Dark-colored urine
• Diarrhea
• Difficulty having a bowel movement (stool)
• Dry mouth
• Feeling of constant movement of self or surroundings
• Hyperventilation
• Increased sweating
• Light-colored stools
• Muscle cramps, pain, or stiffness
• Nausea
• Overactive reflexes
• Poor coordination
• Restlessness
• Sensation of spinning
• Shivering
• Slow heartbeat
• Twitching
• Unusual tiredness or weakness
• Vomiting
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Decreased appetite
• Decreased interest in sexual intercourse
• Inability to have or keep an erection
• Longer than usual time to ejaculation of semen
• Loss in sexual ability, desire, drive, or performance
• Not able to have an orgasm
• Sleepiness or unusual drowsiness
• Sleeplessness

• Change in taste
• Change or problem with discharge of semen
• Chills
• Continuing ringing or buzzing or other unexplained noise in ears
• Decreased weight
• Difficult urination
• Fear or nervousness
• Feeling of warmth
• Hearing loss
• Increased sensitivity of eyes to light
• Jitteriness
• Lack or loss of strength
• Loss of taste
• Not able to ejaculate semen
• Yawning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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