Melphalan (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Chest pain
• Chills
• Cough or hoarseness
• Fever
• Lower back or side pain
• Painful or difficult urination
• Shortness of breath
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen glands
• Unusual bleeding or bruising
• Unusual tiredness or weakness

• Abdominal or stomach pain
• Absent, missed, or irregular menstrual periods
• Back or leg pains
• Bleeding gums
• Bloated abdomen
• Blurred vision
• Clay-colored stools
• Confusion
• Dark urine
• Difficult or labored breathing
• Difficulty swallowing
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Fast, pounding, or irregular heartbeat or pulse
• General body swelling
• Headache
• Hives
• Indigestion
• Itching
• Light-colored stools
• Loss of appetite
• Nausea and vomiting
• Noisy breathing
• Nosebleeds
• Pain and fullness in right upper abdomen
• Pale skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• Rash
• Reddening of the skin, especially around ears swelling of eyes, face, or inside of nose
• Skin rash
• Sore throat
• Sweating
• Swelling of face, hands, ankles, feet, or lower legs
• Tightness in chest
• Unpleasant breath odor
• Unusual lumps or masses
• Vomiting of blood
• Weight gain
• Weight loss
• Wheezing
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Black, tarry stools
• Blood in urine
• Bloody stools
• Change in frequency of urination or amount of urine
• Coma
• Convulsions
• Cracked lips
• Decrease in consciousness
• Diarrhea
• Drowsiness
• Flushing of skin or feeling of warmth
• Increased salivation or sweating
• Increased thirst
• Muscle pain or cramps
• No muscle tone or movement
• Seizures
• Severe nausea and vomiting
• Stomach discomfort, cramps, or tenderness
• Swelling or inflammation of the mouth
• Troubled breathing
• Vomiting of material that looks like coffee grounds
• Watery or bloody diarrhea
• Weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Indigestion
• Passing of gas
• Stomach fullness

• Blue-green to black skin discoloration
• Hair loss, thinning of hair
• Pain, redness, soreness, or sloughing of skin at place of injection
• Sores, welting, or blisters

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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