Bendamustine (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Chest pain
• Chills
• Cough or hoarseness
• Diarrhea
• Fever
• Headache
• Joint pain, stiffness, or swelling
• Lack or loss of strength
• Lower back, side, or stomach pain
• Muscle aches
• Nausea
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Shortness of breath
• Sore throat
• Stuffy or runny nose
• Swelling of the feet or lower legs
• Swollen glands
• Troubled breathing with exertion
• Ulcers, sores, or white spots in the mouth
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting

• Burning or stinging of the skin
• Fast heartbeat
• Hives
• Itching
• Irritation
• Painful cold sores or blisters on the lips, nose, eyes, or genitals
• Rash
• Redness of the skin
• Stiffness or swelling
• Swelling of the eyelids, face, lips, hands, or feet
• Tightness in the chest
• Troubled breathing or swallowing
• Wheezing

• Blistering, flaking, or peeling of the skin
• Difficulty with swallowing
• Dizziness
• Facial swelling
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Decreased weight

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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