Certolizumab Pegol (Subcutaneous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bladder pain
• Bloody or cloudy urine
• Body aches or pain
• Chills
• Cough or hoarseness
• Difficult, burning, or painful urination
• Difficulty with breathing
• Ear congestion
• Fever
• Frequent urge to urinate
• Headache
• Loss of voice
• Lower back or side pain
• Nasal congestion
• Runny nose
• Sneezing
• Sore throat
• Unusual tiredness or weakness

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Chest pain
• Colds or flu-like symptoms
• Frequent urination
• Pain in the ankles or knees
• Pain in the arms or legs
• Painful, red lumps under the skin, mostly on the legs
• Rapid weight gain
• Shortness of breath
• Stomach pain
• Tingling of the hands or feet
• Tightness in the chest
• Troubled breathing
• Unusual weight gain or loss
• Wheezing

• Blurred vision
• Confusion
• Coughing or spitting up blood
• Diarrhea
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fainting
• Feeling of warmth
• General feeling of discomfort, illness, or weakness
• Inflammation of the joints
• Itching
• Joint pain
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of appetite
• Muscle aches
• Nausea
• Night sweats
• Redness of the face, neck, arms and occasionally, upper chest
• Skin rash
• Sudden high fever or low-grade fever for months
• Sweating
• Swelling of the lymph glands
• Weakness

• Blistering, peeling, or loosening of the skin
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Red, scaling, or crusted skin
• Sores, ulcers, or white spots in the mouth or on the lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty with moving
• Muscle pain or stiffness
• Stuffy or runny nose

• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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