Sulfamethoxazole/Trimethoprim (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Black, tarry stools
• Blistering, peeling, or loosening of the skin
• Changes in skin color
• Chest pain
• Chills
• Cough or hoarseness
• Dark urine
• Diarrhea
• Dizziness
• Fever with or without chills
• General feeling of tiredness or weakness
• Headache
• Itching
• Joint or muscle pain
• Light-colored stools
• Loss of appetite
• Lower back or side pain
• Nausea
• Pain, tenderness, or swelling of the foot or leg
• Painful or difficult urination
• Pale skin
• Rash
• Red irritated eyes
• Red skin lesions, often with a purple center
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots in the mouth or on the lips
• Swollen or painful glands
• Tightness in the chest
• Unpleasant breath odor
• Unusual bleeding or bruising
• Vomiting of blood
• Wheezing
• Yellow eyes or skin

• Abdominal or stomach tenderness
• Back, leg, or stomach pains
• Bleeding gums
• Blindness or vision changes
• Blisters, hives, or itching
• Bloating
• Blood in the urine or stools
• Bluish-colored lips, fingernails, or palms
• Burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
• Burning of the face or mouth
• Chest pain
• Cloudy urine
• Confusion
• Constipation
• Continuing ringing or buzzing or other unexplained noise in the ears
• Convulsions
• Cracks in the skin
• Decreased frequency or amount of urine
• Diarrhea, watery and severe, which may also be bloody
• Difficulty with breathing
• Difficulty with swallowing
• Fainting spells
• General body swelling
• General feeling of discomfort or illness
• Hair loss
• Hearing loss
• Hives
• Increased blood pressure
• Increased thirst
• Indigestion
• Irregular heartbeat
• Large, flat, blue, or purplish patches in the skin
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of heat from the body
• Muscle or joint pain
• Nosebleeds
• Not able to pass urine
• Numbness or tingling in the hands, feet, or lips
• Pain or burning while urinating
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Raised red swellings on the skin, the buttocks, legs, or ankles
• Redness of the white part of the eyes
• Redness, swelling, or soreness of the tongue
• Sores, ulcers, or white spots on the lips or in the mouth
• Soreness of the muscles
• Stiff neck or back
• Swelling of the face, hands, legs, and feet
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual weight loss
• Weakness in the hands or feet
• Weakness or heaviness of the legs
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Passing of gas

• Discouragement
• Feeling of constant movement of self or surroundings
• Feeling sad or empty
• Increased sensitivity of skin to sunlight
• Irritability
• Lack of feeling or emotion
• Loss of interest or pleasure
• Nervousness
• Redness or other discoloration of the skin
• Seeing, hearing, or feeling things that are not there
• Sensation of spinning
• Severe sunburn
• Sleeplessness
• Trouble concentrating
• Trouble sleeping
• Unable to sleep
• Uncaring
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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