Desipramine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Actions that are out of control
• Anxiety
• Black, tarry stools
• Bleeding and bruising
• Bleeding gums
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Confusion about identity, place, and time
• Convulsions
• Cough or hoarseness
• Dark urine
• Difficulty in speaking
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Double vision
• Drooling
• Dry mouth
• Fainting
• False beliefs that cannot be changed by facts
• Fear or nervousness
• Headache
• Hyperventilation
• Inability to move arms, legs, or facial muscles
• Inability to speak
• Irregular heartbeat
• Irritability
• Lack of coordination
• Light-colored stools
• Lightheadedness
• Loss of appetite
• Loss of balance control
• Loss of bladder control
• Lower back or side pain
• Muscle spasm or jerking of all extremities
• Muscle trembling, jerking, or stiffness
• Nausea
• Nervousness
• Nightmares
• Pain or discomfort in arms, jaw, back, or neck
• Painful or difficult urination
• Palpitations
• Pinpoint red or purple spots on skin
• Pounding in the ears
• Rash
• Restlessness
• Seeing, hearing, or feeling things that are not there
• Shakiness and unsteady walk
• Shortness of breath
• Shuffling walk
• Sleeplessness
• Slow or fast heartbeat
• Slow speech
• Sore throat and fever
• Sores, ulcers, or white spots on lips or in mouth
• Stiffness of limbs
• Sudden loss of consciousness
• Sweating
• Swelling
• Swelling of testes
• Swollen glands
• Talking, feeling, and acting with excitement
• Trouble sleeping irregular heartbeats
• Twisting movements of body
• Unable to sleep
• Uncontrolled movements, especially of face, neck, and back
• Unpleasant breath odor
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Upper right abdominal pain
• Vomiting
• Vomiting of blood
• Weakness
• Yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Clumsiness
• Decreased awareness or responsiveness
• Drowsiness to profound coma
• Hallucination
• Lethargy
• Low body temperature
• Mood or other mental changes
• Muscle aches
• Severe sleepiness
• Shivering
• Weak or feeble pulse
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach cramps or pain
• Bigger, dilated, or enlarged pupils (black part of eye)
• Bloating
• Constipation
• Decrease in frequency of urination
• Decrease in urine volume
• Decreased interest in sexual intercourse
• Diarrhea
• Difficulty in passing urine (dribbling)
• Hair loss, thinning of hair
• Inability to have or keep an erection
• Increased in sexual ability, desire, drive, or performance
• Increased interest in sexual intercourse
• Increased sensitivity of eyes to light
• Loss in sexual ability, desire, drive, or performance
• Painful urination
• Swelling of the breasts or breast soreness in both females and males
• Swelling or inflammation of the mouth
• Unexpected or excess milk flow from breasts in females

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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