Clomipramine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bladder pain
• Bloody or cloudy urine
• Blurred vision
• Body aches or pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Confusion
• Congestion
• Continuing ringing or buzzing or other unexplained noise in the ears
• Cough
• Difficult, burning, or painful urination
• Discouragement
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Dryness or soreness of the throat
• Excessive muscle tone
• Fear or nervousness
• Feeling sad or empty
• Fever
• Frequent urge to urinate
• Hearing loss
• Hoarseness
• Irritability
• Lack of appetite
• Loss of interest or pleasure
• Lower back or side pain
• Muscle stiffness
• Muscle tension or tightness
• Muscle twitching or jerking
• Pain or tenderness around the eyes and cheekbones
• Poor concentration
• Problems in urination or increase in the amount of urine
• Rhythmic movement of muscles
• Runny nose
• Shortness of breath or troubled breathing
• Sneezing
• Stuffy nose
• Sweating
• Tender, swollen glands in the neck
• Tightness of the chest or wheezing
• Tiredness
• Trouble concentrating
• Trouble remembering
• Trouble sleeping
• Trouble swallowing
• Unusual tiredness or weakness
• Voice changes

• Anger that is hard to control
• Anxiety
• Bloody nose
• Breast enlargement
• Burning, dry, or itching eyes
• Burning while urinating
• Changes in vision
• Chills
• Crying
• Decrease in the frequency of urination
• Decrease in urine volume
• Depersonalization
• Difficulty in passing urine (dribbling)
• Difficulty in speaking
• Discharge or excessive tearing
• Dry mouth
• Dysphoria
• Earache
• Euphoria
• Fast, irregular, pounding, or racing heartbeat or pulse
• Feeling of unreality
• Headache, severe and throbbing
• Hyperventilation
• Increased clear or white vaginal discharge
• Increased watering of the mouth
• Irregular heartbeats
• Irritability
• Itching of the vagina or genital area
• Mental depression
• Nausea or vomiting
• Numbness, tingling, pain, or weakness in the hands or feet
• Pain during sexual intercourse
• Pale skin
• Panic attacks
• Paranoia
• Partial or slight paralysis
• Quick to react or overreact emotionally
• Rapidly changing moods
• Redness or swelling in the ear
• Redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• Restlessness
• Sense of detachment from self or body
• Shaking
• Swelling of the face, fingers, feet, or lower legs
• Thick, white vaginal discharge with no odor or with a mild odor
• Troubled breathing with exertion
• Unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Bad, unusual, or unpleasant aftertaste
• Belching
• Blemishes on the skin
• Blistering, crusting, irritation, itching, or reddening of the skin
• Bloated
• Change in taste
• Change or problem with discharge of semen
• Changes in vision
• Constipation
• Cracked, dry, or scaly skin
• Cramps
• Darkening or lightening of skin color
• Decreased interest in sexual intercourse
• Diarrhea
• Difficulty with moving
• Dry skin
• Excess air or gas in the stomach or intestines
• Feeling of warmth
• Full feeling
• Heartburn
• Heavy bleeding
• Hives or welts
• Inability to have or keep an erection
• Increased appetite
• Increased in sexual ability, desire, drive, or performance
• Increased interest in sexual intercourse
• Indigestion
• Joint pain
• Loss in sexual ability, desire, drive, or performance
• Pain
• Passing gas
• Pimples
• Redness of the face, neck, arms, and occasionally, upper chest
• Redness of the skin
• Shakiness in the legs, arms, hands, or feet
• Skin rash
• Stomach discomfort, upset, or pain
• Swelling
• Swollen joints
• Trembling or shaking of the hands or feet

• Absent, missed, or irregular menstrual periods
• Breast pain
• Increased yawning
• Pinpoint red or purple spots on the skin
• Sores, ulcers, or white spots on the lips or tongue or inside the mouth
• Stopping of menstrual bleeding

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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