Protriptyline (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Actions that are out of control
• Agitation
• Anxiety
• Black, tarry stools
• Bleeding and bruising
• Bleeding gums
• Blood in urine or stools
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Clay-colored stools
• Cold sweats
• Coma
• Confusion about identity, place, and time
• Continuing ringing, buzzing, or other unexplained noise in ears
• Convulsions
• Cool, pale skin
• Cough or hoarseness
• Dark urine
• Decrease in frequency of urination
• Decrease in urine volume
• Decreased urine output
• Depression
• Difficulty in passing urine (dribbling)
• Difficulty in speaking
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Double vision
• Drooling
• Dry mouth
• False beliefs that cannot be changed by facts
• Fast, pounding, or irregular heartbeat or pulse
• Fear or nervousness
• Feeling of warmth
• Feeling, seeing, or hearing things that are not there
• Feeling that others can hear your thoughts
• Feeling that others are watching you or controlling your behavior
• Fever with or without chills
• Flushed, dry skin
• Fruit-like breath odor
• General feeling of tiredness or weakness
• Headache
• Hearing loss
• Hostility
• Hyperventilation
• Inability to move arms, legs, or facial muscles
• Inability to speak
• Increased hunger
• Increased need to urinate
• Increased thirst
• Increased urination
• Irritability
• Itching
• Lack of coordination
• Lethargy
• Loss of appetite
• Loss of balance control
• Lower back or side pain
• Mood or mental changes
• Muscle spasm or jerking of all extremities
• Muscle trembling or twitching
• Nausea
• Nightmares
• Pain or discomfort in arms, jaw, back, or neck
• Painful or difficult urination
• Panic
• Passing urine more often
• Perspiration
• Pinpoint red or purple spots on skin
• Pounding in the ears
• Rapid weight gain
• Rash
• Redness of the face, neck, arms, and occasionally, upper chest
• Restlessness
• Seizures
• Shakiness and unsteady walk
• Shortness of breath
• Shuffling walk
• Sleeplessness
• Slow speech
• Slurred speech
• Sore throat
• Sores, ulcers, or white spots on lips or in mouth
• Stiffness of limbs
• Stupor
• Sudden loss of consciousness
• Sweating
• Swelling of face, ankles, or hands
• Swollen glands
• Talking, feeling, and acting with excitement
• Trouble in holding or releasing urine
• Trouble sleeping
• Twisting movements of body uncontrolled movements, especially of face, neck, and back
• Unable to sleep
• Unpleasant breath odor
• Unsteadiness or awkwardness
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual behavior
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of blood
• Weakness in arms, hands, legs, or feet
• Weight gain or loss
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Change in consciousness
• Clumsiness
• Decreased awareness or responsiveness
• Difficulty sleeping
• Disorientation
• Disturbed concentration
• Drowsiness to profound coma
• Enlarged pupils
• Increased or excessive unconscious or jerking movements
• Loss of consciousness
• Low body temperature
• Muscle aches
• Muscle tightness
• Muscle weakness
• Shivering
• Severe sleepiness
• Trouble breathing
• Weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal cramps
• Bigger, dilated, or enlarged pupils (black part of eye)
• Black tongue
• Bloating
• Decreased interest in sexual intercourse
• Diarrhea
• Difficulty having a bowel movement (stool)
• Disturbance of accommodation
• Enlargement of the breasts
• Hair loss, thinning of hair
• Heartburn
• Hives or welts
• Inability to have or keep an erection
• Increased in sexual ability, desire, drive, or performance
• Increased interest in sexual intercourse
• Increased sensitivity of eyes to light
• Increased sensitivity of skin to sunlight
• Increased urge to urinate during the night
• Loss in sexual ability, desire, drive, or performance
• Pain or discomfort in chest, upper stomach, or throat
• Peculiar taste
• Redness or other discoloration of skin
• Severe sunburn
• Small red or purple spots on skin
• Swelling of testicles
• Swelling of the breasts or breast soreness in both females and males
• Swelling or inflammation of the mouth
• Swollen, painful, or tender lymph glands on side of face or neck
• Unexpected or excess milk flow from breasts
• Waking to urinate at night

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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