Naltrexone (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Body aches or pain
• Chills
• Congestion
• Cough
• Difficulty with breathing
• Discouragement
• Dryness or soreness of the throat
• Ear congestion
• Fear
• Feeling sad or empty
• Fever
• Headache
• Hoarseness
• Irritability
• Lack of appetite
• Loss of interest or pleasure
• Loss of voice
• Nasal congestion
• Nervousness
• Rash
• Runny nose
• Sneezing
• Sore throat
• Tender, swollen glands in the neck
• Trouble concentrating
• Trouble sleeping
• Trouble with swallowing
• Unusual tiredness or weakness
• Voice changes

• Abdominal or stomach cramps or pain
• Arm, back, or jaw pain
• Black, tarry stools
• Bladder pain
• Bloating
• Bloody or cloudy urine
• Bloody stools
• Blurred vision
• Chest pain or discomfort
• Chest tightness or heaviness
• Chills
• Confusion
• Confusion as to time, place, or person
• Constipation
• Cough
• Cough producing mucus
• Decreased urination
• Diarrhea
• Difficult, burning, or painful urination
• Dilated neck veins
• Dizziness or lightheadedness
• Dry mouth
• Extreme fatigue
• Fainting
• False or unusual sense of well-being
• Fast, irregular, pounding, or racing heartbeat or pulse
• Frequent urge to urinate
• General feeling of discomfort or illness
• Hallucinations or seeing, hearing, or feeling things that are not there
• Headache, severe and throbbing
• Holding false beliefs that cannot be changed by fact
• Hyperventilation
• Increase in heart rate
• Increase in white blood cells
• Indigestion
• Irregular breathing
• Irritability
• Itching, pain, redness, swelling, tenderness, or warmth on the skin
• Joint or muscle pain
• Lightheadedness
• Lower back or side pain
• Nausea
• Nervousness
• Numbness or tingling of the face, hands, or feet
• Pain or discomfort in the arms, jaw, back, or neck
• Pain, redness, or swelling in the arm or leg
• Pounding in the ears
• Rapid breathing
• Redness and soreness of the eyes
• Restlessness
• Seizures
• Severe nausea or vomiting
• Shaking
• Shivering
• Shortness of breath
• Skin rash
• Slow or fast heartbeat
• Sores in the mouth
• Stomach cramps
• Stomach pain
• Sudden shortness of breath or troubled breathing
• Sunken eyes
• Sweating
• Swelling of the face, fingers, feet, or lower legs
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Tenderness
• Thirst
• Tightness in the chest
• Tooth or gum pain
• Trouble sleeping
• Troubled breathing
• Unusual excitement, nervousness, or restlessness
• Vomiting
• Vomiting of blood or material that looks like coffee grounds
• Watery or bloody diarrhea
• Weight gain
• Wheezing
• Wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty with moving
• Muscle stiffness
• Swelling or redness in the joints

• Bleeding after defecation
• Bloated
• Change in taste
• Decreased interest in sexual intercourse
• Drowsiness
• Excess air or gas in the stomach or intestines
• Feeling of warmth
• Feeling unusually cold
• Full feeling
• Heartburn
• Inability to have or keep an erection
• Increased sweating
• Loss in sexual ability, desire, drive, or performance
• Loss of taste
• Night sweats
• Passing gas
• Redness of the face, neck, arms, and occasionally, upper chest
• Relaxed and calm
• Sleepiness
• Stuffy nose
• Sudden sweating
• Toothache
• Uncomfortable swelling around anus
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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