Glyburide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Hives
• Itching
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Tightness in the chest
• Unusual tiredness or weakness
• Wheezing

• Abdominal or stomach pain
• Chills
• Clay-colored stools
• Dark urine
• Diarrhea
• Fever
• Headache
• Light-colored stools
• Loss of appetite
• Nausea and vomiting
• Rash
• Unpleasant breath odor
• Upper right abdominal pain
• Vomiting of blood
• Yellow eyes and skin

• Agitation
• Back, leg, or stomach pains
• Bleeding gums
• Blood in the urine or stools
• Bloody, black, or tarry stools
• Blurred vision
• Change in near or distance vision
• Chest pain
• Coma
• Confusion
• Convulsions
• Cough or hoarseness
• Decreased urine output
• Depression
• Difficulty in focusing eyes
• Difficulty with breathing
• Fast or irregular heartbeat
• Fluid-filled skin blisters
• General body swelling
• High fever
• Hostility
• Increased thirst
• Irritability
• Itching of the skin
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Lethargy
• Lower back or side pain
• Muscle pain or cramps
• Muscle twitching
• Nosebleeds
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Rapid weight gain
• Seizures
• Sensitivity to the sun
• Skin thinness
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stupor
• Swelling of the face, ankles, or hands
• Swollen or painful glands
• Unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

• Anxiety
• Cold sweats
• Cool, pale skin
• Increased hunger
• Nervousness
• Nightmares
• Shakiness
• Slurred speech

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Indigestion
• Passing of gas

• Difficulty with moving
• Itching
• Joint pain
• Redness or other discoloration of the skin
• Severe sunburn
• Swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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