Ciprofloxacin (Intravenous Route)
Original Article: http://www.mayoclinic.com/health/drug-information/DR602779
US Brand Names
Canadian Brand Names
Ciprofloxacin injection is used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection after inhalational exposure.
Ciprofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin injection in children. However, because of this medicine's toxicity, it should be used with caution, after other alternatives have been considered and/or found ineffective. Ciprofloxacin injection may be used in children to prevent anthrax infection after possible exposure, and to treat serious kidney infections.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ciprofloxacin injection in the elderly. However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving ciprofloxacin injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
- Guar Gum
- Insulin Aspart, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Perflutren Lipid Microsphere
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Mycophenolate Mofetil
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Brain or spinal cord disease, including hardening of the arteries in the brain or epilepsy or other seizures or
- Diabetes or
- Diarrhea or
- Heart rhythm problems (e.g., prolonged QT interval) or
- Hypokalemia (low potassium in the blood), uncorrected—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of this medicine from the body.
- Myasthenia gravis (severe muscle weakness)—Should not be used in patients with this condition.
- Organ transplant (e.g., kidney, heart, or lung) or
- Tendon disorder (e.g., rheumatoid arthritis), history of—Use with caution. May increase the risk of tendon problems.
A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will remain in place for about an hour.
Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
Your doctor will give you or your child a few doses of this medicine until your condition improves, and then you or your child may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.
If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.
Do not take tizanidine (Zanaflex®) while you are receiving this medicine. Tell your doctor if you or your child are also using theophylline (Theo-Dur®) or other products that contain caffeine (e.g., coffee, soda, chocolate). Using these medicines together may increase risks for more serious side effects.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.
Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you or your child are using this medicine.
Stop using this medicine and check with your doctor right away if you or your child have dark urine, clay-colored stools, abdominal or stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem.
Some people who receive ciprofloxacin injection may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you or your child begin receiving this medicine:
- Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
- Wear protective clothing, including a hat and sunglasses.
- Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
- Do not use a sunlamp or tanning bed or booth.
If you have a severe reaction from the sun, check with your doctor.
Ciprofloxacin injection may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that can be dangerous if you are dizzy or not alert. If these reactions are especially bothersome, check with your doctor.
Ciprofloxacin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.
This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.
Ciprofloxacin may rarely cause inflammation or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are using the medicine or after you finish using it. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (e.g., dexamethasone, prednisolone, prednisone, or Medrol®), have severe kidney problems, have a history of tendon problems (e.g., rheumatoid arthritis), or if you have received an organ transplant (e.g., heart, kidney, or lung). Stop using this medicine and check with your doctor right away if you have sudden pain or swelling in a tendon after exercise (e.g., ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.
For diabetic patients taking diabetes medicine by mouth: Ciprofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you or your child experience symptoms of low blood sugar, stop taking levofloxacin and check with your doctor right away:
- Symptoms of low blood sugar can include: Anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty with concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Less common
- Black, tarry stools
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- Chest pain
- Painful or difficult urination
- Shortness of breath
- Sore throat
- Sores, ulcers, or white spots on the lips or in the mouth
- Swollen glands
- Unusual bleeding or bruising
- Unusual tiredness or weakness
- Abdominal or stomach cramps or pain
- Abdominal or stomach tenderness
- Actions that are out of control
- Aggressive and violent behavior
- Ankle, knee, or great toe joint pain
- Arm, back, or jaw pain
- Back or side pain
- Blistering, peeling, or loosening of the skin
- Blisters under the skin
- Bloody or cloudy urine
- Blue lips and fingernails
- Blurred vision
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- Change in walking and balance
- Changes in skin color, pain, tenderness, or swelling of the foot or leg
- Chest tightness or heaviness
- Clay-colored stools
- Clumsiness or unsteadiness
- Cold, clammy, or pale skin
- Cough or hoarseness
- Coughing or spitting up blood
- Coughing that sometimes produces a pink frothy sputum
- Cracks in the skin
- Darkening of the skin
- Decreased frequency or amount of urine
- Delusions of persecution, mistrust, suspiciousness, or combativeness
- Diarrhea, watery and severe, which may also be bloody
- Difficult or labored breathing
- Difficult, fast, noisy breathing, sometimes with wheezing
- Difficulty in passing urine (dribbling)
- Difficulty with breathing, chewing, swallowing, or talking
- Difficulty with moving
- Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- Double vision
- Drooping eyelids
- Fast, slow, irregular, pounding, or racing heartbeat or pulse
- Fear or nervousness
- Feeling of unreality
- Feeling of warmth or heat
- Feeling sad or empty
- Fever with or without chills
- Flushing or redness of the skin, especially on the face and neck
- Frequent urination
- General feeling of tiredness or weakness
- Greatly decreased frequency of urination or amount of urine
- Groin pain
- Headache, severe and throbbing
- Heart stops
- Hives or welts
- Increased perspiration
- Increased sensitivity of the skin to sunlight
- Increased sweating
- Increased thirst
- Increased volume of pale, dilute urine
- Irregular heartbeats
- Itching of the vagina or genital area
- Itching skin
- Joint or muscle pain
- Joint stiffness or swelling
- Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- Light-colored stools
- Loss of ability to use or understand speech or language
- Loss of appetite
- Loss of bladder control
- Loss of heat from the body
- Loss of interest or pleasure
- Lower abdominal or stomach cramping
- Lower back or side pain
- Mood or mental changes
- Muscle pain or stiffness
- Muscle spasm or jerking of all extremities
- Muscle weakness
- Nausea and vomiting
- No breathing
- No pulse or blood pressure
- Noisy breathing
- Numbness of hands
- Pain during sexual intercourse
- Pain in the ankles or knees
- Pain or discomfort in the arms, jaw, back, or neck
- Painful oral mucosa
- Painful, red lumps under the skin, mostly on the legs
- Pains in the stomach, side, or abdomen, possibly radiating to the back
- Pale skin
- Pinpoint red or purple spots on the skin
- Pounding in the ears
- Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- Red skin lesions, often with a purple center
- Red, irritated eyes
- Red, swollen skin
- Redness of the face, neck, arms, and occasionally, upper chest
- Redness or other discoloration of the skin
- Scaly skin
- Seeing, hearing, or feeling things that are not there
- Sense of detachment from self or body
- Severe constipation
- Severe sunburn
- Severe tiredness
- Severe vomiting
- Shakiness and unsteady walk
- Shakiness in the legs, arms, hands, or feet
- Slow or irregular breathing
- Small red or purple spots on the skin
- Sores, welting, or blisters
- Sudden decrease in the amount of urine
- Sudden loss of consciousness
- Sudden shortness of breath or troubled breathing
- Swelling of the lips, face, neck, eyes, hands, or lower extremities
- Swelling of the lymph nodes
- Talking, feeling, and acting with excitement
- Thick, white vaginal discharge with no odor or with a mild odor
- Tightness in the chest
- Trouble concentrating
- Trouble sleeping
- Troubled breathing
- Unable to sleep
- Unpleasant breath odor
- Unsteadiness, trembling, or other problems with muscle control or coordination
- Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- Unusual weight gain
- Unusual weight loss
- Upper right abdominal pain
- Vomiting of blood
- Weight gain
- Yellow eyes and skin
- Bleeding and bruising
- Bleeding gums
- Bluish-colored lips, fingernails, or palms
- Bone pain
- Confusion as to time, place, or person
- Excessive muscle tone
- Feeling of discomfort
- General body swelling
- High fever
- Holding false beliefs that cannot be changed by fact
- Increased sensitivity to pain or touch
- Inflammation of the joints
- Muscle aches
- Muscle tension or tightness
- Muscle twitching or jerking
- Pain, inflammation, or swelling in the calves, shoulders, or hands
- Painful, swollen joints
- Rhythmic movement of muscles
- Stomach pain, continuing
- Swollen glands
- Uncontrolled eye movements
- Unexplained bleeding or bruising
- Unsteadiness or awkwardness
- Unusual excitement, nervousness, or restlessness
- Weakness in the arms, hands, legs, or feet
- Weakness or heaviness of the legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Acid or sour stomach
- Runny nose
- Stomach discomfort, upset, or pain
- Stuffy nose
- Changes in vision
- Continuing ringing or buzzing or other unexplained noise in the ears
- Decreased vision
- Dry mouth
- Excess air or gas in the stomach or intestines
- Eye pain
- Full feeling
- Hearing loss
- Loss of sense of smell
- Overbright appearance of lights
- Passing gas
- Seeing double
- Seeing shades of colors differently than before
- Sore mouth or tongue
- Swelling of the breasts or breast soreness in both females and males
- White patches in the mouth and/or on the tongue
- Loss of taste
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.