Milnacipran (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Blurred vision
• Body aches or pain
• Chills
• Cough
• Difficulty with breathing
• Dizziness
• Ear congestion
• Fast, irregular, pounding, or racing heartbeat or pulse
• Fear or nervousness
• Fever
• Headache
• Increased sweating
• Loss of voice
• Nasal congestion
• Pounding in the ears
• Runny nose
• Slow or fast heartbeat
• Sneezing
• Sore throat
• Unusual tiredness or weakness

• Back pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest discomfort
• Chest pain
• Chills
• Decrease in frequency of urination
• Decrease in urine volume
• Difficult or painful urination
• Difficulty in passing urine (dribbling)
• Frequent urination
• Groin pain
• Muscle aches
• Pain or burning with urination
• Shakiness in the legs, arms, hands, or feet
• Shortness of breath
• Swollen, tender prostate
• Tightness in the chest
• Wheezing

• Bladder pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Bloody or cloudy urine
• Bruise
• Discouragement
• Fall
• Feeling sad or empty
• Frequent urge to urinate
• Full or bloated feeling
• Heartburn
• Increased or decreased weight
• Irritability
• Lack of appetite
• Loss of interest or pleasure
• Lower back or side pain
• Pressure in the stomach
• Rapid weight gain
• Swelling of the abdominal or stomach area
• Tingling of the hands or feet
• Tiredness
• Trouble concentrating
• Trouble sleeping
• Unusual weight gain or loss
• Vomiting

• Agitation
• Black, tarry stools
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Blood in the urine or stools
• Coma
• Confusion as to time, place, or person
• Convulsions
• Dark-colored urine
• Decreased urine output
• Diarrhea
• Difficulty with swallowing
• General tiredness and weakness
• High fever
• Holding false beliefs that cannot be changed by fact
• Increased sweating
• Increased thirst
• Itching
• Joint or muscle pain
• Light-colored stools
• Loss of balance control
• Loss of consciousness
• Mask-like face
• Muscle cramps or spasms
• Muscle pain or stiffness
• Overactive reflexes
• Pinpoint red spots on the skin
• Poor coordination
• Red irritated eyes
• Red skin lesions, often with a purple center
• Restlessness
• Seeing, hearing, or feeling things that are not there
• Seizures
• Severe muscle stiffness
• Shuffling walk
• Slowed movements
• Slurred speech
• Sores, ulcers, or white spots on the lips or in the mouth
• Stiffness of the arms and legs
• Sweating
• Swelling of the face, ankles, fingers, or lower legs
• Swollen glands
• Talking or acting with excitement you cannot control
• Tic-like (jerky) movements of the head, face, mouth, and neck
• Tiredness
• Trembling and shaking of the fingers and hands
• Twitching
• Unusual bleeding or bruising
• Unusual excitement, nervousness, or restlessness
• Unusually pale skin
• Upper right abdominal pain
• Weight gain
• Yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Feeling of warmth
• Headache, severe and throbbing
• Redness of the face, neck, arms, and occasionally, upper chest
• Sleeplessness
• Sudden sweating
• Unable to sleep

• Abdominal or stomach pain
• Change or problem with discharge of semen
• Decreased appetite
• Decreased interest in sexual intercourse
• Inability to have or keep an erection
• Loss in sexual ability, desire, drive, or performance
• Not able to ejaculate semen
• Rash
• Swelling of the testes

• Acid or sour stomach
• Belching
• Bloated
• Change in taste
• Excess air or gas in the stomach or intestines
• Full feeling
• Heartburn
• Indigestion
• Irritability
• Loss of taste
• Night sweats
• Passing gas
• Sleepiness or unusual drowsiness
• Stomach discomfort, upset, or pain

• Swelling of the breasts or unusual milk production
• Unexpected or excess milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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